Evidence map›Paper›PMID 39006763›Full record

ArticleMedComm2024

DNMT3A dysfunction promotes neuroinflammation and exacerbates acute ischemic stroke.

Tian-Jie Lyu, Xin Qiu, Yubo Wang, Ling Zhang, Yalun Dai, Xuechun Wang, Shunying Zhao, Meilin Xiang, Lu Cui, Si Cheng and 15 more

Abstract read
In one paragraph

Article in MedComm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Tian-Jie LyuDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.ORCID https://orcid.org/0000-0002-1934-8643
Xin QiuDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Yubo WangDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Ling ZhangDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Yalun DaiDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Xuechun WangDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Shunying ZhaoChina National Clinical Research Center for Neurological Diseases Beijing China.
Meilin XiangChina National Clinical Research Center for Neurological Diseases Beijing China.
Lu CuiChina National Clinical Research Center for Neurological Diseases Beijing China.
Si ChengDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Yang LiuChina National Clinical Research Center for Neurological Diseases Beijing China.
Hongqiu GuChina National Clinical Research Center for Neurological Diseases Beijing China.
Yong JiangChina National Clinical Research Center for Neurological Diseases Beijing China.
Xia MengDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Yilong WangDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Xingquan ZhaoDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Xianwei WangCenter for Metabolic Disease Research Lewis Katz School of Medicine Temple University Philadelphia Pennsylvania USA.
Qian LiDepartment of Biochemistry and Molecular Biology School of Basic Medical Sciences Capital Medical University Beijing China.
Meng WangChina National Clinical Research Center for Neurological Diseases Beijing China.
Yingyu JiangChina National Clinical Research Center for Neurological Diseases Beijing China.
Zhe XuChina National Clinical Research Center for Neurological Diseases Beijing China.
Xinying HuangChina National Clinical Research Center for Neurological Diseases Beijing China.
Hao LiChina National Clinical Research Center for Neurological Diseases Beijing China.
Yongjun WangDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.
Zixiao LiDepartment of Neurology Beijing Tiantan Hospital Capital Medical University Beijing China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Somatic mutations related to clonal hematopoiesis of indeterminate potential (CHIP) are risk factors for stroke. The impact of

Indexed as

clonal hematopoiesisDNMT3Afunctional outcomeproinflammatoryRG108

Identifiers

PMID39006763
PMCPMC11246610

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.