Evidence map›Paper›PMID 39006524›Full record

ReviewNeuro-oncology practice2024

Biomarkers of immunotherapy in glioblastoma.

William M Savage, Mitchell D Yeary, Anthony J Tang, Colin P Sperring, Michael G Argenziano, Arjun R Adapa, Nina Yoh, Peter Canoll, Jeffrey N Bruce

Abstract readReview
In one paragraph

Review in Neuro-oncology practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
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  7. Review
  8. Killing the killers: Natural killer cell therapy targeting glioma stem cells in high-grade glioma.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William M SavageDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.ORCID https://orcid.org/0000-0001-6864-8485
Mitchell D YearyDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.ORCID https://orcid.org/0000-0002-3542-372X
Anthony J TangDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.ORCID https://orcid.org/0000-0003-2016-0389
Colin P SperringDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.
Michael G ArgenzianoDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.
Arjun R AdapaDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.
Nina YohDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.
Peter CanollDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.ORCID https://orcid.org/0000-0002-7001-0226
Jeffrey N BruceDepartment of Neurological Surgery, Columbia University Irving Medical Center/NY-Presbyterian Hospital, New York, New York, USA.

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Single Cell Analysis of the Infiltrative Margins of Glioblastoma and Post Treatment RecurrenceR01NS103473 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JEFFREY N BRUCE, Peter Canoll · 2017 to 2026
$4.3M
CHRONIC CONVECTION ENHANCED DELIVERY (CED) OF TOPOTECAN FOR GLIOBLASTOMAR01CA161404 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRUCE, JEFFREY N · 2012 to 2017
$2.9M
The Brief Research in Aging and Interdisciplinary NeurosciencesT35AG044303 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sachin Agarwal, Jennifer Jaie Manly · 2013 to 2026
$1.9M
NCI NIH HHS P30 CA013696NCI NIH HHS R01 CA161404NIA NIH HHS T35 AG044303NINDS NIH HHS R01 NS103473
6 · The paper itself

Abstract

Glioblastoma (GBM) is the most common primary brain cancer, comprising half of all malignant brain tumors. Patients with GBM have a poor prognosis, with a median survival of 14-15 months. Current therapies for GBM, including chemotherapy, radiotherapy, and surgical resection, remain inadequate. Novel therapies are required to extend patient survival. Although immunotherapy has shown promise in other cancers, including melanoma and non-small lung cancer, its efficacy in GBM has been limited to subsets of patients. Identifying biomarkers of immunotherapy response in GBM could help stratify patients, identify new therapeutic targets, and develop more effective treatments. This article reviews existing and emerging biomarkers of clinical response to immunotherapy in GBM. The scope of this review includes immune checkpoint inhibitor and antitumoral vaccination approaches, summarizing the variety of molecular, cellular, and computational methodologies that have been explored in the setting of anti-GBM immunotherapies.

Indexed as

biomarkerscancer immunotherapycancer vaccineglioblastomaimmune checkpoint inhibitor

Identifiers

PMID39006524
PMCPMC11241363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.