Evidence map›Paper›PMID 39006494›Full record

ArticleJournal of inflammation research2024

Single-Cell Analysis Identifies Distinct Populations of Cytotoxic CD4

Xu Yang, Jianwei Wu, Longlong Fan, Binghua Chen, Shiqiang Zhang, Wenzhong Zheng

Abstract read
In one paragraph

Article in Journal of inflammation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Cytotoxic CD4Signal transduction and targeted therapy · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Targeting PD-1 and CD85j can restore intratumoral CD4Journal for immunotherapy of cancer · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xu Yang *Department of Urology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.ORCID 0009-0004-2734-3203
Jianwei Wu *Department of Urology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.
Longlong FanDepartment of Urology, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, People's Republic of China.
Binghua ChenDepartment of Urology, Pingtan Branch of Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.
Shiqiang ZhangDepartment of Urology, Kidney and Urology Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, People's Republic of China.
Wenzhong ZhengDepartment of Urology, Fujian Medical University Union Hospital, Fuzhou, People's Republic of China.ORCID 0000-0001-5242-4671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The involvement of cytotoxic CD4 Methods: Utilizing single-cell RNA sequencing, we analyzed the immunophenotype and expression patterns of CD4 Results: Single-cell analysis of CD4 Conclusion: Our study underscores the pivotal role that intratumoral CD4

Indexed as

cytotoxic CD4+ T cellsgranzyme K and granzyme Bimmune checkpoint inhibitorsrenal cell carcinomasingle-cell analysis

Identifiers

PMID39006494
PMCPMC11246657

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.