Evidence map›Paper›PMID 39006156›Full record

ArticleNature catalysis2024

Biocatalytic, Enantioenriched Primary Amination of Tertiary C-H Bonds.

Runze Mao, Shilong Gao, Zi-Yang Qin, Torben Rogge, Sophia J Wu, Zi-Qi Li, Anuvab Das, K N Houk, Frances H Arnold

Abstract read
In one paragraph

Article in Nature catalysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Biocatalytic Radical C(spResearch square · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Enantioconvergent benzylic C(spScience (New York, N.Y.) · 2025
    Article
  13. Photoinduced Copper-Catalyzed Enantioselective Allylic C(Journal of the American Chemical Society · 2025
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Runze MaoDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125, United States.
Shilong GaoDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125, United States.
Zi-Yang QinDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125, United States.
Torben RoggeDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Sophia J WuDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125, United States.
Zi-Qi LiDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125, United States.
Anuvab DasDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125, United States.
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States.
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125, United States.

Funding

Abiological Enzymatic C–H Functionalization for Bioactive Molecule Construction and DiversificationR01GM138740 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ARNOLD, FRANCES H · 2020 to 2023
$1.5M
NIGMS NIH HHS R01 GM138740
6 · The paper itself

Abstract

Intermolecular functionalization of tertiary C-H bonds to construct fully substituted stereogenic carbon centers represents a formidable challenge: without the assistance of directing groups, state-of-the-art catalysts struggle to introduce chirality to racemic tertiary s

Identifiers

PMID39006156
PMCPMC11238567

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.