Evidence map›Paper›PMID 39005869›Full record

ArticleIndian journal of clinical biochemistry : IJCB2024

Association Between Serum Levels of Anti-heat Shock Protein 27 Antibody and Liver Cell Injury in Chronic Hepatitis B.

Zahra Yousefli, Zahra Meshkat, Majid Ghayour-Mobarhan, Seyed Mousalreza Hosseini, Shima Tavallaie, Ehsan Kazemianfar, Hossein Soltanian, Afarin Aminzadeh, Amirhosein Ghasemi, Maryam Kashmari and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of clinical biochemistry : IJCB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zahra YousefliFaculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra MeshkatAntimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Majid Ghayour-MobarhanMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Seyed Mousalreza HosseiniDepartment of Gastroenterology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Shima TavallaieMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Ehsan KazemianfarStudent Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein SoltanianStudent Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
Afarin AminzadehStudent Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
Amirhosein GhasemiStudent Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam KashmariStudent Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammadreza NasiraeeStudent Research Committee, Faculty of Paramedical Science, Mashhad University of Medical Sciences, Mashhad, Iran.
Mojtaba MeshkatDepartment of Community Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran.
Lida JarrahiDepartment of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Aida GholoobiMetabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0001-6399-1612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat Shock Protein 27 (HSP27), an anti-HBV factor, exists in the intracellular and extracellular spaces. As an inflammatory modulator, serum HSP27 (sHSP27) is associated with elevated pro-inflammatory cytokines and a higher likelihood of hepatocellular carcinoma in chronic hepatitis. SHSP27 results in natural antibody production (anti-HSP27-Ab) that is more stable and easily detectable compared to sHSP27. We aimed to investigate any potential association between anti-HSP27-Ab level and chronic hepatitis B (CHB) progression and inflammation indicated by liver cell injury and HBV replication. This cross-sectional study was conducted on 91 patients with CHB and 92 individuals without CHB. Following demographic data collection, anti-HSP27-Ab, serum lipids including total cholesterol, triglyceride, LDL-C, HDL-C, and aminotransferase levels were measured using enzymatic assays in participants' serum samples. HBV DNA was also measured by quantitative PCR in CHB patients. Bivariate and multivariate analyses showed a significantly higher mean level of anti-HSP27-Ab in CHB than in healthy individuals (0.304 vs. 0.256AU/ml,

Indexed as

Anti-heat shock protein 27 antibodyChronic hepatitis BHBV DNAHepatitis B virusSerum lipid

Identifiers

PMID39005869
PMCPMC11239617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.