Evidence map›Paper›PMID 39005672›Full record

ArticleAmerican journal of cancer research2024

PDK3 drives colorectal carcinogenesis and immune evasion and is a therapeutic target for boosting immunotherapy.

Zhiqiang Liu, Liang Li, Lei Liu, Zhengming Zhu, Yi Yu, Shaochao Zhan, Zepeng Luo, Yuchen Li, He Long, Jing Cai and 2 more

Abstract read
In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhiqiang LiuDepartment of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College Nanchang 330006, Jiangxi, China.
Liang LiDepartment of Emergency, Jiangxi Maternal and Child Health Hospital Nanchang 330006, Jiangxi, China.
Lei LiuDepartment of General Surgery, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Zhengming ZhuDepartment of General Surgery, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Yi YuDepartment of Urology Surgery, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Shaochao ZhanDepartment of Urology Surgery, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Zepeng LuoDepartment of Urology Surgery, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Yuchen LiDepartment of Gastrointestinal Surgery, Jiangxi Provincial Cancer Hospital Nanchang 330029, Jiangxi, China.
He LongDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Jing CaiDepartment of Oncology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Kai HuangDepartment of Gastrointestinal Surgery, Jiangxi Provincial Cancer Hospital Nanchang 330029, Jiangxi, China.
Xiaohong DuDepartment of Anesthesiology, The Second Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyruvate Dehydrogenase Kinase 3 (PDK3) has emerged as a significant player in various cancer types, yet its specific impact on cancers including colon cancer remains ambiguous. Through pan-cancer analysis using TCGA data, we found that the expression of

Indexed as

Colorectal cancerimmune infiltrationPyruvate Dehydrogenase Kinase 3

Identifiers

PMID39005672
PMCPMC11236793

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.