Evidence map›Paper›PMID 39005664›Full record

ArticleAmerican journal of cancer research2024

Developing a comprehensive molecular subgrouping model for cervical cancer using machine learning.

Gwan Hee Han, Hae-Rim Kim, Hee Yun, Joon-Yong Chung, Jae-Hoon Kim, Hanbyoul Cho

Abstract read
In one paragraph

Article in American journal of cancer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gwan Hee HanDepartment of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University College of Medicine Seoul 01757, Republic of Korea.
Hae-Rim KimDepartment of Statistics, College of Natural Science, University of Seoul Seoul 02504, Republic of Korea.
Hee YunDepartment of Obstetrics and Gynecology, Gangnam Severance Hospital, Yonsei University College of Medicine Seoul 06299, Republic of Korea.
Joon-Yong ChungMolecular Imaging Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda, MD 20892, USA.
Jae-Hoon KimDepartment of Obstetrics and Gynecology, Yonsei University College of Medicine Seoul 03722, Republic of Korea.
Hanbyoul ChoDepartment of Obstetrics and Gynecology, Yonsei University College of Medicine Seoul 03722, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study developed a molecular classification model for cervical cancer using machine learning, integrating prognosis related biomarkers with clinical features. Analyzing 281 specimens, 27 biomarkers were identified, associated with recurrence and treatment response. The model identified four molecular subgroups: group 1 (OALO) with Overexpression of ATP5H and LOw risk; group 2 (LASIM) with low expression of ATP5H and SCP, indicating InterMediate risk; group 3 (LASNIM) characterized by Low expression of ATP5H, SCP, and NANOG, also at InterMediate risk; and group 4 (LASONH), with Low expression of ATP5H, and SCP, Over expression of NANOG, indicating High risk, and potentially aggressive disease. This classification correlated with clinical outcomes such as tumor stage, lymph node metastasis, and response to treatment, demonstrating that combining molecular and clinical factors could significantly enhance the prediction of recurrence and aid in personalized treatment strategies for cervical cancer.

Indexed as

Artificial intelligencecervical cancermachine learningprognosis

Identifiers

PMID39005664
PMCPMC11236797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.