Evidence map›Paper›PMID 39005609›Full record

ArticleIranian journal of microbiology2024

Antibacterial and antibiofilm activities of zingerone and niosomal zingerone against methicillin-resistant

Laleh Larijanian, Morvarid Shafiei, Abdollah Ghasemi Pirbalouti, Atousa Ferdousi, Mohsen Chiani

Abstract read
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Article in Iranian journal of microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Laleh LarijanianDepartment of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Morvarid ShafieiDepartment of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Abdollah Ghasemi PirbaloutiDepartment of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Atousa FerdousiDepartment of Microbiology, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
Mohsen ChianiDepartment of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Methicillin-resistant Materials and Methods: 62 MRSA isolates cultured from patients with diabetic ulcers were investigated. Niosomes were synthesized and characterized by X-ray diffraction, zeta potential and scanning electron microscopy (SEM). The size of niosomal particles measured by SEM and zetasizer. Results: The surface charge of prepared niosomes was about -37 mV. The effect of the zingerone and noisome containing zingerone was evaluated against biofilms of MRSA isolates. Also, the antibiofilm activity of prepared niosomes on gene expression of MRSA biofilms was evaluated using Real Time PCR. Our results demonstrated that the niosome containing zingerone had a diameter of 196.1 nm and a -37.3-mV zeta potential. Zingerone removed one and three-day old biofilms of MRSA at the concentration of 1000 μg/ml, while the zingerone-laoded niosomes removed 1, 3- and 5-days old biofilms at the concentration of 250 μg/ml, 250 μg/ml, and 500 μg/ml. Conclusion: The results indicated that niosome containing zingerone eliminated MRSA and its biofilms faster compared with free zingerone and it suggested that zingerone-encapsulated niosomes could be considered as a promising treatment against MRSA and its biofilms.

Indexed as

BiofilmMethicillin resistant Staphylococcus aureusNiosomesZingerone

Identifiers

PMID39005609
PMCPMC11245341

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