Evidence map›Paper›PMID 39005485›Full record

ReviewPatterns (New York, N.Y.)2024

Recent methodological advances in federated learning for healthcare.

Fan Zhang, Daniel Kreuter, Yichen Chen, Sören Dittmer, Samuel Tull, Tolou Shadbahr, BloodCounts! consortium, Jacobus Preller, James H F Rudd, John A D Aston and 3 more

Abstract readReview
In one paragraph

Review in Patterns (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The potential of artificial intelligence in clinical trials.European journal of clinical investigation · 2026
    Review
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  7. Review
  8. Article
  9. Review
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  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
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  20. Solving the 'Goldilocks problem' in dementia clinical trials with multimodal AI.The journal of prevention of Alzheimer's disease · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fan ZhangDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Daniel KreuterDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Yichen ChenDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Sören DittmerDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Samuel TullDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Tolou ShadbahrResearch Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
BloodCounts! consortium
Jacobus PrellerAddenbrooke's Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK.
James H F RuddDepartment of Medicine, University of Cambridge, Cambridge, UK.
John A D AstonDepartment of Pure Mathematics and Mathematical Statistics, University of Cambridge, Cambridge, UK.
Carola-Bibiane SchönliebDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.
Nicholas GleadallDepartment of Haematology, University of Cambridge, Cambridge, UK.
Michael RobertsDepartment of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For healthcare datasets, it is often impossible to combine data samples from multiple sites due to ethical, privacy, or logistical concerns. Federated learning allows for the utilization of powerful machine learning algorithms without requiring the pooling of data. Healthcare data have many simultaneous challenges, such as highly siloed data, class imbalance, missing data, distribution shifts, and non-standardized variables, that require new methodologies to address. Federated learning adds significant methodological complexity to conventional centralized machine learning, requiring distributed optimization, communication between nodes, aggregation of models, and redistribution of models. In this systematic review, we consider all papers on Scopus published between January 2015 and February 2023 that describe new federated learning methodologies for addressing challenges with healthcare data. We reviewed 89 papers meeting these criteria. Significant systemic issues were identified throughout the literature, compromising many methodologies reviewed. We give detailed recommendations to help improve methodology development for federated learning in healthcare.

Indexed as

applicationsbest practicesdeploymentfederated learninghealthcaremachine learningmethodological advancesprivacysecuritysystematic review

Identifiers

PMID39005485
PMCPMC11240178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.