Evidence map›Paper›PMID 39005429›Full record

ArticlebioRxiv : the preprint server for biology2025

Heuristic energy-based cyclic peptide design.

Qiyao Zhu, Vikram Khipple Mulligan, Dennis Shasha

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Qiyao ZhuCenter for Computational Biology, Flatiron Institute, New York, NY, U.S.A.ORCID 0000-0002-9184-0683
Vikram Khipple MulliganCenter for Computational Biology, Flatiron Institute, New York, NY, U.S.A.ORCID 0000-0001-6038-8922
Dennis ShashaCourant Institute of Mathematical Sciences, New York University, New York, NY, U.S.A.ORCID 0000-0002-7036-3312

Funding

Hit-and-Run transcription: The impact of transient interactions in dynamic gene regulatory networks that mediate rapid nutrient signalingR01GM121753 · NIGMS · NEW YORK UNIVERSITY · PI CORUZZI, GLORIA, SHASHA, DENNIS ELLIOTT · 2020 to 2023
$1.7M
NIGMS NIH HHS R01 GM121753
6 · The paper itself

Abstract

Rational computational design is crucial to the pursuit of novel drugs and therapeutic agents. Meso-scale cyclic peptides, which consist of 7-40 amino acid residues, are of particular interest due to their conformational rigidity, binding specificity, degradation resistance, and potential cell permeability. Because there are few natural cyclic peptides,

Identifiers

PMID39005429
PMCPMC11244984

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.