Evidence map›Paper›PMID 39005427›Full record

ArticlebioRxiv : the preprint server for biology2024

Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma.

Jung Hyun Um, Yueyuan Zheng, Qiong Mao, Chehyun Nam, Hua Zhao, Yoon Woo Koh, Su-Jin Shin, Young Min Park, De-Chen Lin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jung Hyun UmDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Yueyuan ZhengClinical Big Data Research Center, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, P.R. China.
Qiong MaoClinical Big Data Research Center, Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen 518107, P.R. China.
Chehyun NamCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Hua ZhaoCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.
Yoon Woo KohDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Su-Jin ShinDepartment of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Young Min ParkDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
De-Chen LinCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, USA.

Funding

Master regulator transcription factors promote esophageal neoplastic evolutionR37CA237022 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LIN, DE-CHEN · 2020 to 2025
$2.7M
Pharmacological and dietary inhibition of a novel metabolic-epigenetic crosstalk in head and neck cancerR01DE033648 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI De-Chen Lin · 2024 to 2026
$1.5M
NCI NIH HHS R37 CA237022NIDCR NIH HHS R01 DE033648
6 · The paper itself

Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) remains a significant health burden due to tumor heterogeneity and treatment resistance, emphasizing the need for improved biological understanding and tailored therapies. This study enrolled 31 HNSCC patients for the establishment of patient-derived tumor organoids (PDOs), which faithfully maintained genomic features and histopathological traits of primary tumors. Long-term culture preserved key characteristics, affirming PDOs as robust representative models. PDOs demonstrated predictive capability for cisplatin treatment responses, correlating

Indexed as

drug responsegenomic mutationintratumor heterogeneitysingle-cell transcriptomic analysisTumor organoid

Identifiers

PMID39005427
PMCPMC11244938

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.