ArticlebioRxiv : the preprint server for biology2024
CRF release from a unique subpopulation of accumbal neurons constrains action-outcome acquisition in reward learning.
Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The nucleus accumbens (NAc) mediates reward learning and motivation. Despite an abundance of neuropeptides, peptidergic neurotransmission from the NAc has not been integrated into current models of reward learning. The existence of a sparse population of neurons containing corticotropin releasing factor (CRF) has been previously documented. Here we provide a comprehensive analysis of their identity and functional role in shaping reward learning. Methods: To do this, we took a multidisciplinary approach that included florescent in situ hybridization (N Results: Here we show that the vast majority of NAc CRF-containing (NAc Conclusion: We conclude that CRF release from this sparse population of SPNs is critical for reward learning under normal conditions.
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