Evidence map›Paper›PMID 39005408›Full record

ArticlebioRxiv : the preprint server for biology2024

Endothelial Zmiz1 modulates physiological and pathophysiological angiogenesis during retinal development.

Nehal R Patel, K C Rajan, Mark Y Chiang, Stryder M Meadows

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nehal R PatelDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, United States.
K C RajanDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, United States.ORCID 0000-0003-1121-3661
Mark Y ChiangDivision of Hematology-Oncology, Department of Internal Medicine, Medical School, University of Michigan, Ann Arbor, MI, United States.
Stryder M MeadowsDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA, United States.ORCID 0000-0003-0968-7155

Funding

Angiopoietin-2 Signaling Targeted Therapeutics for Arteriovenous MalformationsR01HL163196 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI MARAMBAUD, PHILIPPE, MEADOWS, STRYDER MEDOAH · 2022 to 2025
$2.7M
Stage-specific roles for Zmiz1 in Notch-dependent steps of early T-cell developmentR01AI136941 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHIANG, MARK Y · 2019 to 2023
$2.5M
Molecular mechanisms underlying Arteriovenous Malformations associated with HHTR01HL139713 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI MEADOWS, STRYDER MEDOAH · 2018 to 2022
$1.8M
NHLBI NIH HHS R01 HL139713NHLBI NIH HHS R01 HL163196NIAID NIH HHS R01 AI136941
6 · The paper itself

Abstract

Angiogenesis is a highly coordinated process involving the control of various endothelial cell behaviors. Mechanisms for transcription factor involvement in the regulation of endothelial cell dynamics and angiogenesis have become better understood, however much remains unknown, especially the role of non-DNA binding transcriptional cofactors. Here, we show that Zmiz1, a transcription cofactor, is enriched in the endothelium and critical for embryonic vascular development, postnatal retinal angiogenesis, and pathological angiogenesis in oxygen induced retinopathy (OIR). In mice, endothelial cell-specific deletion of

Indexed as

angiogenesisco-factorretinopathytranscriptionZmiz1

Identifiers

PMID39005408
PMCPMC11244917

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.