Evidence map›Paper›PMID 39005376›Full record

ArticlebioRxiv : the preprint server for biology2024

Disruption of the PGE

Emanuela Ricciotti, Soon Yew Tang, Antonijo Mrčela, Ujjalkumar S Das, Ronan Lordan, Robin Joshi, Soumita Ghosh, Justin Aoyama, Ryan McConnell, Jianing Yang and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emanuela RicciottiInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Soon Yew TangInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Antonijo MrčelaInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Ujjalkumar S DasInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Ronan LordanInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Robin JoshiInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Soumita GhoshInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Justin AoyamaInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Ryan McConnellInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Jianing YangInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Gregory R GrantInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.
Garret A FitzGeraldInstitute for Translational Medicine and Therapeutics, Perelman School of Medicine.

Funding

Atherosclerosis, Prostaglandin Inhibition and Checkpoint BlockadeR01HL141912 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2019 to 2022
$2.6M
NHLBI NIH HHS R01 HL141912
6 · The paper itself

Abstract

Immune checkpoint inhibitors (ICIs) that target programmed cell death 1 (PD-1) have revolutionized cancer treatment by enabling the restoration of suppressed T-cell cytotoxic responses. However, resistance to single-agent ICIs limits their clinical utility. Combinatorial strategies enhance their antitumor effects, but may also enhance the risk of immune related adverse effects of ICIs. Prostaglandin (PG) E

Identifiers

PMID39005376
PMCPMC11244953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.