Evidence map›Paper›PMID 39005365›Full record

ArticlebioRxiv : the preprint server for biology2024

N

Bradley S Jones, Vikram Pareek, Daniel D Hu, Simon D Weaver, Camille Syska, Grace Galfano, Matthew M Champion, Patricia A Champion

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    N2025
5 · Who and what money

Authors and funding

8 authors.

Bradley S Jones
Vikram Pareek
Daniel D Hu
Simon D Weaver
Camille Syska
Grace Galfano
Matthew M ChampionORCID 0000-0001-5927-5277
Patricia A ChampionORCID 0000-0002-6733-596X

Funding

Role of N-alpha acetylation in mycobacterial secretion and virulenceR01AI106872 · NIAID · UNIVERSITY OF NOTRE DAME · PI CHAMPION, PATRICIA A · 2013 to 2024
$4.2M
NIAID NIH HHS R01 AI106872
6 · The paper itself

Abstract

Phagosomal lysis is a key aspect of mycobacterial infection of host macrophages. Acetylation is a protein modification mediated enzymatically by N-acetyltransferases (NATs) that impacts bacterial pathogenesis and physiology. To identify NATs required for lytic activity, we leveraged Significance Statement: Acetylation is a modification of protein N-termini, lysine residues, antibiotics and lipids. Many of the enzymes that promote acetylation belong to the GNAT family of proteins.

Identifiers

PMID39005365
PMCPMC11245092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.