Evidence map›Paper›PMID 39005328›Full record

ArticlebioRxiv : the preprint server for biology2024

An orbitocortical-thalamic circuit suppresses binge alcohol-drinking.

P Gimenez-Gomez, T Le, M Zinter, P M'Angale, V Duran-Laforet, T G Freels, R Pavchinskiy, S Molas, D P Schafer, A R Tapper and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

P Gimenez-GomezBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
T LeBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
M ZinterBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
P M'AngaleBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
V Duran-LaforetBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
T G FreelsBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
R PavchinskiyBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
S MolasInstitute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO 80303, USA.
D P SchaferBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
A R TapperBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
T ThomsonBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
G E MartinBrudnick Neuropsychiatric Research Institute, Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.ORCID 0000-0001-6611-9678

Funding

Microglia-dependent mechanisms governing neural circuit plasticityR01MH113743 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dorothy Patricia Schafer · 2017 to 2026
$4.9M
The mesointerpeduncular circuit in anxiety and nicotine withdrawalR01DA041482 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANDREW R TAPPER · 2017 to 2026
$4.0M
The role of familiarity neurocircuitry in novelty seekingR01DA047678 · NIDA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI TAPPER, ANDREW R · 2019 to 2023
$2.4M
Effects of binge alcohol drinking on synaptic computing in the nucleus accumbensR01AA027807 · NIAAA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MARTIN, GILLES E · 2020 to 2024
$2.3M
IMSD at the University of Massachusetts Medical SchoolT32GM135751 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRIAN C LEWIS, Kate L Lapane · 2020 to 2026
$2.2M
How Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA · 2021 to 2025
$2.2M
The role of a novel viral-like signalling pathway in synaptic plasticity and neurological disordersR01NS112492 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI THOMSON, TRAVIS · 2019 to 2023
$1.8M
Dissecting the impact of senescence on microglia function and neurodegenerationRF1AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2020 to 2020
$1.7M
NIAAA NIH HHS R01 AA027807NIA NIH HHS RF1 AG068281NIDA NIH HHS R01 DA041482NIDA NIH HHS R01 DA047678NIGMS NIH HHS T32 GM135751NIMH NIH HHS R01 MH113743NINDS NIH HHS R01 NS112492NINDS NIH HHS R01 NS117533
6 · The paper itself

Abstract

Alcohol consumption remains a significant global health challenge, causing millions of direct and indirect deaths annually. Intriguingly, recent work has highlighted the prefrontal cortex, a major brain area that regulates inhibitory control of behaviors, whose activity becomes dysregulated upon alcohol abuse. However, whether an endogenous mechanism exists within this brain area that limits alcohol consumption is unknown. Here we identify a discrete GABAergic neuronal ensemble in the medial orbitofrontal cortex (mOFC) that is selectively recruited during binge alcohol-drinking and intoxication. Upon alcohol intoxication, this neuronal ensemble suppresses binge drinking behavior. Optogenetically silencing of this population, or its ablation, results in uncontrolled binge alcohol consumption. We find that this neuronal ensemble is specific to alcohol and is not recruited by other rewarding substances. We further show, using brain-wide analysis, that this neuronal ensemble projects widely, and that its projections specifically to the mediodorsal thalamus are responsible for regulating binge alcohol drinking. Together, these results identify a brain circuit in the mOFC that serves to protect against binge drinking by halting alcohol intake. These results provide valuable insights into the complex nature of alcohol abuse and offers potential avenues for the development of mOFC neuronal ensemble-targeted interventions.

Identifiers

PMID39005328
PMCPMC11245026

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.