Evidence map›Paper›PMID 39005323›Full record

ArticlebioRxiv : the preprint server for biology2024

Influenza A defective viral genome production is altered by metabolites, metabolic signaling molecules, and cyanobacteria extracts.

Ilechukwu Agu, Ivy R José, Samuel L Díaz-Muñoz

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ilechukwu AguDepartment of Microbiology and Molecular Genetics University of California, Davis One Shields Ave Davis CA 95616.
Ivy R JoséDepartment of Microbiology and Molecular Genetics University of California, Davis One Shields Ave Davis CA 95616.
Samuel L Díaz-MuñozDepartment of Microbiology and Molecular Genetics University of California, Davis One Shields Ave Davis CA 95616.ORCID 0000-0003-2967-9806

Funding

The basis of Influenza A virus strain-dependent reassortment potentialR01AI179873 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Samuel L Diaz · 2024 to 2026
$1.3M
Dissecting the drivers of avian influenza virus reassortment in the wild bird reservoirR00AI119401 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DIAZ, SAMUEL L · 2017 to 2018
$493k
NIAID NIH HHS R00 AI119401NIAID NIH HHS R01 AI179873
6 · The paper itself

Abstract

RNA virus infections are composed of a diverse mix of viral genomes that arise from low fidelity in replication within cells. The interactions between "defective" and full-length viral genomes have been shown to shape pathogenesis, leading to intense research into employing these to develop novel antivirals. In particular, Influenza A defective viral genomes (DVGs) have been associated with milder clinical outcomes. Yet, the full potential of DVGs as broad-spectrum antivirals remains untapped due to the unknown mechanisms of their

Identifiers

PMID39005323
PMCPMC11245085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.