Evidence map›Paper›PMID 39005314›Full record

ArticlebioRxiv : the preprint server for biology2024

Toxic Small Alarmone Synthetase FaRel2 inhibits translation by pyrophosphorylating tRNA

Tatsuaki Kurata, Masaki Takegawa, Takayuki Ohira, Egor A Syroegin, Gemma C Atkinson, Marcus J O Johansson, Yury S Polikanov, Abel Garcia-Pino, Tsutomu Suzuki, Vasili Hauryliuk

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Tatsuaki KurataDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID 0000-0001-5986-7141
Masaki TakegawaDepartment of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113-8656.
Takayuki OhiraDepartment of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113-8656.
Egor A SyroeginDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Gemma C AtkinsonDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID 0000-0002-4861-4584
Marcus J O JohanssonDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID 0000-0001-7117-7426
Yury S PolikanovDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.ORCID 0000-0002-5064-0327
Abel Garcia-PinoCellular and Molecular Microbiology, Faculté des Sciences, Université libre de Bruxelles (ULB), Boulevard du Triomphe, Building BC, (1C4 203), 1050 Brussels, Belgium.ORCID 0000-0002-0634-0300
Tsutomu SuzukiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo, Bunkyo-ku, Tokyo 113-8656.
Vasili HauryliukDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID 0000-0003-2389-5057

Funding

Molecular mechanisms of action of ribosome-targeting antibiotics.R01GM132302 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2019 to 2022
$1.3M
NIGMS NIH HHS R01 GM132302
6 · The paper itself

Abstract

Translation-targeting toxic Small Alarmone Synthetases (toxSAS) are effectors of bacterial Toxin-Antitoxin systems that pyrophosphorylate the 3'-CCA end of tRNA to prevent aminoacylation. toxSAS are implicated in antiphage immunity: phage detection triggers the toxSAS activity to shut down viral production. We show that the toxSAS FaRel2 inspects the tRNA acceptor stem to specifically select tRNA

Indexed as

antiphage immunitytoxin-antitoxinstranslationtRNA

Identifiers

PMID39005314
PMCPMC11245113

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.