Evidence map›Paper›PMID 39005302›Full record

ArticlebioRxiv : the preprint server for biology2024

Polyunsaturated Fatty Acid - mediated Cellular Rejuvenation for Reversing Age-related Vision Decline.

Fangyuan Gao, Emily Tom, Cezary Rydz, William Cho, Alexander V Kolesnikov, Yutong Sha, Anastasios Papadam, Samantha Jafari, Andrew Joseph, Ava Ahanchi and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Fangyuan GaoGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.
Emily TomDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, CA.
Cezary RydzDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, CA.
William ChoDepartment of Physiology and Biophysics, School of Medicine, University of California Irvine, CA.
Alexander V KolesnikovGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.
Yutong ShaDepartment of Mathematics, University of California Irvine, CA.
Anastasios PapadamInstitute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Samantha JafariGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.
Andrew JosephGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.
Ava AhanchiGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.
Nika Balalaei Someh SaraeiGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.
David LyonDepartment of Anatomy and Neurobiology, School of Medicine, University of California Irvine, CA.
Andrzej FoikInternational Centre for Translational Eye Research, Institute of Physical Chemistry, Polish Academy of Sciences, Warsaw, Poland.ORCID 0000-0003-1110-9223
Qing NieDepartment of Mathematics, University of California Irvine, CA.
Felix GrassmannInstitute for Clinical Research and System Medicine, Health and Medical University, Potsdam, Germany.
Vladimir J KefalovGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.
Dorota Skowronska-KrawczykGavin Herbert Eye Institute - Center for Translational Vision Research, Department of Ophthalmology, University of California Irvine, CA, 92697, USA.ORCID 0000-0003-1110-9223

Funding

NEI UCI Center Core Grant for Vision ResearchP30EY034070 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI James V Jester · 2022 to 2026
$3.7M
Correlating Genomic AMD Risk Variants with Lipid Composition and Phagocytic Function of Patient-Derived Induced Pluripotent Stem Cell (iPSC)-derived Retinal Pigment Epithelium (RPE)U01EY034594 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SKOWRONSKA-KRAWCZYK, DOROTA, WAHLIN, KARL J · 2022 to 2025
$1.6M
Modulation of cone photoreceptor function by autophagyR01EY035137 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Thomas Almon Ferguson, Vladimir Jivkov Kefalov · 2023 to 2026
$1.5M
Visual Sciences Training Program (VSTP)T32EY032448 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Philip David Kiser, Chang C Liu · 2022 to 2026
$656k
Role of ELOVL2 in age-related visual declineF30EY035146 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Emily Tom · 2024 to 2026
$154k
NEI NIH HHS F30 EY035146NEI NIH HHS P30 EY034070NEI NIH HHS R01 EY035137NEI NIH HHS T32 EY032448NEI NIH HHS U01 EY034594
6 · The paper itself

Abstract

The retina is uniquely enriched in polyunsaturated fatty acids (PUFAs), which are primarily localized in cell membranes, where they govern membrane biophysical properties such as diffusion, permeability, domain formation, and curvature generation. During aging, alterations in lipid metabolism lead to reduced content of very long-chain PUFAs (VLC-PUFAs) in the retina, and this decline is associated with normal age-related visual decline and pathological age-related macular degeneration (AMD).

Indexed as

AMDELOVL2lipid supplementationPUFAVLC-PUFA

Identifiers

PMID39005302
PMCPMC11244954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.