Evidence map›Paper›PMID 39005258›Full record

ArticlebioRxiv : the preprint server for biology2024

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4.

Femke M Feringa, Sascha J Koppes-den Hertog, Lian Wang, Rico J E Derks, Iris Kruijff, Lena Erlebach, Jorin Heijneman, Ricardo Miramontes, Nadine Pömpner, Niek Blomberg and 17 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Femke M FeringaCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.ORCID 0000-0002-6003-4048
Sascha J Koppes-den HertogCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Lian WangLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.
Rico J E DerksLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.
Iris KruijffCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Lena ErlebachGerman Center for Neurodegenerative Diseases (DZNE) Tübingen, Tübingen, Germany.
Jorin HeijnemanCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Ricardo MiramontesDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Nadine PömpnerLeibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
Niek BlombergLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.
Damien Olivier-JimenezLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.
Lill Eva JohansenCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.ORCID 0000-0003-2187-6709
Alexander J CammackDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Ashling GiblinDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Christina E ToomeyDepartment of Clinical and Molecular Neuroscience, Queen Square Institute of Neurology, University College London, London, UK.
Indigo V L RoseInstitute for Neurodegenerative Diseases and Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
Hebao YuanNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Michael WardNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Adrian M IsaacsDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Martin KampmannDepartment of Biochemistry and Biophysics, Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3819-7019
Deborah Kronenberg-VersteegGerman Center for Neurodegenerative Diseases (DZNE) Tübingen, Tübingen, Germany.
Tammaryn LashleyDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.
Leslie M ThompsonDepartment of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
Alessandro OriLeibniz Institute on Aging, Fritz Lipmann Institute, Jena, Germany.
Yassene MohammedLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.
Martin GieraLeiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, the Netherlands.ORCID 0000-0003-1684-1894
Rik van der KantCenter for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam, the Netherlands.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Project 3: Neuropathology of the multi-proteinopathy of c9FTD/ALS.P01NS084974 · NINDS · MAYO CLINIC JACKSONVILLE · PI PETRUCELLI, LEONARD · 2014 to 2024
$17.6M
Predoctoral Training in NeurobiologyT32NS115706 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMUEL JEREMY PLEASURE · 2020 to 2026
$3.4M
NCI NIH HHS P30 CA062203NINDS NIH HHS P01 NS084974NINDS NIH HHS T32 NS115706
6 · The paper itself

Abstract

Lipid changes in the brain have been implicated in many neurodegenerative diseases including Alzheimer's Disease (AD), Parkinson's disease and Amyotrophic Lateral Sclerosis. To facilitate comparative lipidomic research across brain-diseases we established a data commons named the Neurolipid Atlas, that we have pre-populated with novel human, mouse and isogenic induced pluripotent stem cell (iPSC)-derived lipidomics data for different brain diseases. We show that iPSC-derived neurons, microglia and astrocytes display distinct lipid profiles that recapitulate

Identifiers

PMID39005258
PMCPMC11244892

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.