Evidence map›Paper›PMID 39005231›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

An Ultrasensitive Biosensor for Probing Subcellular Distribution and Mitochondrial Transport of l-2-Hydroxyglutarate.

Zhaoqi Kang, Shuang Hou, Kaiyu Gao, Yidong Liu, Ning Zhang, Zhiqing Fang, Wen Zhang, Xianzhi Xu, Rong Xu, Chuanjuan Lü and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhaoqi KangState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Shuang HouState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Kaiyu GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Yidong LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Ning ZhangDepartment of Breast Surgery, General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250100, P. R. China.
Zhiqing FangDepartment of Urology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250100, P. R. China.
Wen ZhangInstitute of Medical Sciences, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250100, P. R. China.
Xianzhi XuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Rong XuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Chuanjuan LüState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Cuiqing MaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.
Ping XuState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
Chao GaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China.ORCID 0000-0002-5205-0670

Funding

China Postdoctoral Science Foundation 2023M742085National Key Research and Development Program of China 2019YFA0904800National Natural Science Foundation of China 32170112National Natural Science Foundation of China 32270074Qingdao Postdoctoral Research Project QDBSH20230201011State Key Laboratory of Microbial Technology SKLMTFCP-2023-03Youth Program of National Natural Science Foundation of China 32300029Youth Program of National Natural Science Foundation of China 32300045Youth Program of Natural Science Foundation of Qingdao City 23-2-1-31-zyyd-jchYouth Program of Natural Science Foundation of Shandong Province ZR2023QC237
6 · The paper itself

Abstract

l-2-Hydroxyglutarate (l-2-HG) is a functionally compartmentalized metabolite involved in various physiological processes. However, its subcellular distribution and mitochondrial transport remain unclear owing to technical limitations. In the present study, an ultrasensitive l-2-HG biosensor, sfLHGFR

Indexed as

Biosensing TechniquesGlutaratesMitochondriaBiological TransportHEK293 CellsHumansalpha-hydroxyglutarateGlutaratesbiosensorl‐2‐hydroxyglutaratemetabolismmitochondrial transportpoint‐of‐care testing

Identifiers

PMID39005231
PMCPMC11425224

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.