Evidence map›Paper›PMID 39005122›Full record

ArticleCurrent drug metabolism2024

UPLC-LTQ-Orbitrap Study on Rat Urinary Metabolites of 5-Methoxy-Alpha-Methyltryptamine.

Guo Zhutao, Keran Ding, Shuiqing Zheng, Chunfang Ni, Chen Liang, Siyang He, Qianya Deng

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Article in Current drug metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Guo ZhutaoDepartment of Toxicants and Narcotics Examination Office, Shanghai Municipal Public Security Bureau, Shanghai, 200083, PR China.
Keran DingDepartment of Toxicants and Narcotics Examination Office, Shanghai Municipal Public Security Bureau, Shanghai, 200083, PR China.
Shuiqing ZhengDepartment of Toxicants and Narcotics Examination Office, Shanghai Municipal Public Security Bureau, Shanghai, 200083, PR China.
Chunfang NiDepartment of Toxicants and Narcotics Examination Office, Shanghai Municipal Public Security Bureau, Shanghai, 200083, PR China.
Chen LiangDepartment of Toxicants and Narcotics Examination Office, Shanghai Municipal Public Security Bureau, Shanghai, 200083, PR China.
Siyang HeDepartment of Toxicants and Narcotics Examination Office, Shanghai Municipal Public Security Bureau, Shanghai, 200083, PR China.
Qianya DengDepartment of Toxicants and Narcotics Examination Office, Shanghai Municipal Public Security Bureau, Shanghai, 200083, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective5-Methoxy-α-Methyltryptamine (5-MeO-AMT) is a new psychoactive substance which is abused due to its hallucinogenic and euphoric effects. This study aimed to study the metabolic characteristics of 5-MeO-AMT.

methodsFive rats were given intraperitoneal injection at a dose of 50 mg/kg of 5-MeO-AMT, and their urine was subsequently collected at different times within 7 days. Ultra-high performance liquid chromatographytandem high-resolution mass spectrometry (UPLC-LTQ-Orbitrap) was used to detect the precise molecular weight and fragment ions of 5-MeO-AMT and its possible metabolites in the urine sample extracted with benzene-ethyl acetate.

resultsThree metabolites, including OH-5-MeO-AMT, α-Me-5-HT, and N-Acetyl-5-MeO-AMT were identified in rats' urine. The major metabolic pathways involved O-demethylation, hydroxylation of indole ring, and Acetylation on aliphatic amines.

conclusionThe results of this study are an important reference for the identification and screening of toxicants of 5-MeO-AMT.

Indexed as

Rats, Sprague-Dawley5-MethoxytryptamineAnimalsChromatography, High Pressure LiquidHallucinogensMaleMass SpectrometryRats5-MethoxytryptamineHallucinogens5-MeO-AMThallucinationshigh resolution.metabolic pathwaymetabolitesUPLC-LTQ-Orbitrap

Identifiers

PMID39005122

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.