Evidence map›Paper›PMID 39005114›Full record

ArticleInternational journal of cancer2024

COVID-19 vaccinated children, adolescents, and young adults with acute lymphoblastic leukemia show spike reactive antibodies and multifunctional T-cells.

Rebecca S Parker, Justin Le, Miguel Villa, Annie Luong, Tsen Yin Lin, Yesun Lee, Andrew Doan, Paibel Aguayo-Hiraldo, Pia S Pannaraj, Seon-Jae Yoon and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rebecca S ParkerChildren's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, California, Los Angeles, USA.
Justin LeChildren's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, California, Los Angeles, USA.
Miguel VillaChildren's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, California, Los Angeles, USA.
Annie LuongThe Saban Research institute, Children's Hospital Los Angeles, California, Los Angeles, USA.
Tsen Yin LinThe Saban Research institute, Children's Hospital Los Angeles, California, Los Angeles, USA.
Yesun LeeDivision of Infectious Diseases, Children's Hospital Los Angeles, California, Los Angeles, USA.
Andrew DoanChildren's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, California, Los Angeles, USA.
Paibel Aguayo-HiraldoChildren's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, California, Los Angeles, USA.
Pia S PannarajDivision of Infectious Diseases, Children's Hospital Los Angeles, California, Los Angeles, USA.
Seon-Jae YoonChildren's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, California, Los Angeles, USA.
William Dean WallaceDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
April ArmstrongDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Maurice R O'GormanDepartment of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jennifer Dien BardDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, California, USA.
Chintan ParekhChildren's Center for Cancer and Blood Disease, Children's Hospital Los Angeles, California, Los Angeles, USA.ORCID 0000-0001-8100-9151

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
Longitudinal SARS-CoV-2 mRNA vaccine-induced mucosal, serological, and cellular immunity in children and human milkR01AI173194 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pia S Pannaraj · 2022 to 2026
$4.0M
Children's Cancer Research FundConcern FoundationMalibu Triathlon FoundationNCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1TR000130NCATS NIH HHS UL1 TR001855NCATS NIH HHS UL1TR001855NIAID NIH HHS R01 AI173194Saban Research InstituteW. M. Keck Foundation
6 · The paper itself

Abstract

Little is known about the efficacy of COVID-19 vaccines during acute lymphoblastic leukemia therapy (ALL); data for COVID-19 vaccine immune responses in pediatric leukemia remain sparse. We conducted a single center study of patients aged 5-25 years undergoing ALL chemotherapy who received COVID-19 vaccination. Twenty-one patients were enrolled; efficacy was evaluable in 20. Twenty were vaccinated while receiving chemotherapy. Twenty received the BNT162b2 mRNA vaccine. Spike reactive antibodies (S-IgG) and/or T-cells (SRT) were detected in 16 of 20 (80%) vaccinated patients; 13 (65%) and 9 (45%) were positive for S-IgG and SRT, respectively. Six (30%) showed both spike reactive B and T-cell responses. Eleven of the 13 with S-IgG positivity were negative for anti-Nucleocapsid IgG, an antibody profile consistent with a vaccine induced immune response. All 13S-IgG+ patients showed neutralizing antibodies. SRT included CD4+ (7) and CD8+ (6) T-cells; both CD4+ and CD8+ SRT were seen in 4. SRT were multifunctional (producing multiple cytokines) in most patients (8 of 9); 4 showed SRT with triple cytokine and B-cell co-stimulatory responses, indicating a multimodal adaptive immune response. Immune responses were seen among patients vaccinated in the settings of lymphopenia (6 of 12) intensive chemotherapy (3 of 4), and Peg allergy (6 of 8). Sequencing revealed public CD4+ and CD8+ TCR sequences reactive to epitopes across the spike protein. In conclusion, COVID-19 vaccination induced B and/or T-cell responses in a majority of children and young adults undergoing ALL chemotherapy.

Indexed as

Antibodies, ViralBNT162 VaccineCOVID-19COVID-19 VaccinesPrecursor Cell Lymphoblastic Leukemia-LymphomaSARS-CoV-2AdolescentAdultAntibodies, NeutralizingChildChild, PreschoolFemaleHumansImmunoglobulin GMaleSpike Glycoprotein, CoronavirusAntibodies, NeutralizingAntibodies, ViralBNT162 VaccineCOVID-19 VaccinesImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID‐19 vaccinepediatric ALLT‐cell response

Identifiers

PMID39005114
PMCPMC11499007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.