Evidence map›Paper›PMID 39005061›Full record

ReviewCurrent gene therapy2024

The Functions and Application Prospects of Hepatocyte Growth Factor in Reproduction.

Xin Mi, Caiyi Chen, Chen Feng, Yingying Qin, Zi-Jiang Chen, Yajuan Yang, Shidou Zhao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current gene therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin MiInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
Caiyi ChenInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
Chen FengInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
Yingying QinInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
Zi-Jiang ChenInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
Yajuan YangInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.
Shidou ZhaoInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, Shandong, 250012, China.ORCID 0000-0003-4722-1575

Funding

National Key Research and Development Program of China 2022YFC2703800, 2021YFC2700100National Natural Science Foundation for Distinguished Young Scholars 82125014National Natural Science Foundation of China 32170867, 32370906Natural Science Foundation of Shandong Province ZR2021ZD33Research Unit of Gametogenesis and Health of ART-Offspring, Chinese Academy of Medical Sciences 2020RU001Shandong Provincial Key Research and Development Program 2020ZLYS02Taishan Scholars Program for Young Experts of Shandong Province tsqn202211370
6 · The paper itself

Abstract

Hepatocyte growth factor (HGF) is expressed in multiple systems and mediates a variety of biological activities, such as mitosis, motility, and morphogenesis. A growing number of studies have revealed the expression patterns and functions of HGF in ovarian and testicular physiology from the prenatal to the adult stage. HGF regulates folliculogenesis and steroidogenesis by modulating the functions of theca cells and granulosa cells in the ovary. It also mediates somatic cell proliferation and steroidogenesis, thereby affecting spermatogenesis in males. In addition to its physiological effects on the reproductive system, HGF has shown advantages in preclinical studies over recent years for the treatment of male and female infertility, particularly in women with premature ovarian insufficiency. This review aims to summarize the pleiotropic functions of HGF in the reproductive system and to provide prospects for its clinical application.

Indexed as

Hepatocyte Growth FactorAnimalsFemaleGranulosa CellsHumansMaleOvaryReproductionSpermatogenesisTestisHepatocyte Growth Factorc-MetHepatocyte growth factormorphogenesis.ovaryreproductiontestis

Identifiers

PMID39005061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.