ArticleESC heart failure2024
Changes in waiting time, need for mechanical circulatory support and outcomes in paediatric heart transplant recipients.
Article in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Clinical Deterioration in Stage 1 and 2 Single Ventricle Patients Awaiting Heart Transplant: A Single Center Experience.Pediatric cardiology · 2026Article
- Contributing Factors to Infectious Disease Risk and Vaccine Strategy Optimization in Cardiac Surgery Patients.Vaccines · 2026Review
- Current availability and status of paediatric cardiac transplantation and mechanical circulatory support in twenty-eight European countries.European journal of pediatrics · 2026Article
- Less Invasive Acute Rejection Surveillance After Pediatric Heart Transplantation: Experiences From a Low-intensity Biopsy Center.Transplantation direct · 2026Article
- A Single-Center Real-World Experience: Early and Long-Term Outcomes of Pediatric Heart Transplantation with or Without a Left Ventricular Assist Device Bridging.Journal of clinical medicine · 2026Article
- Elevated filling pressures are associated with poor long-term graft survival after pediatric heart transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Article
- Comprehensive Analysis of the First 35 Years of Pediatric Heart Transplantation in Sweden.Pediatric transplantation · 2025Article
- Changes in waiting time, need for mechanical circulatory support and outcomes in paediatric heart transplant recipients.ESC heart failure · 2024Article
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Authors and funding
9 authors.
Funding
Abstract
aimsHeart transplantation is a well-established treatment for end-stage heart failure in paediatric patients, demonstrating excellent long-term outcomes.
methodsThis retrospective study analyses 35 years of data on 244 paediatric recipients (<18 years) at a single institution from 1986 to 2022. The analysis explores changes in diagnoses, survival, waiting times and mechanical circulatory support (MCS) over three decades (1991-2000, 2001-2010 and 2011-2020).
resultsSurvival outcomes significantly improved over the study period, with 1-year survival rates increasing from 79.3% (1991-2000) to 92.3% (2011-2020, P = 0.041). The median overall survival was 18.0 years, and median conditional survival to 1 year post-transplant was 20.9 years. Survival differences were noted among age groups, with infants under 1 year of age experiencing higher early mortality, and adolescents (aged 11-17 years) facing increased long-term risks, possibly linked to adult donor characteristics. Waiting times for heart transplantation increased, especially for younger age groups (0-5 and 6-10 years), reflecting the growing demand for donor organs. The use of MCS, including ventricular assist devices (VAD), surged, with 67% of recipients in the most recent decade receiving pre-transplant VAD support. Importantly, despite prolonged waiting times and increased VAD use, overall survival continued to be favourable.
conclusionsEarly and long-term results after paediatric heart transplantation have been continuously improving over the past decades. Despite an increased demand for donor organs and the growing reliance on VAD as bridge to transplantation, post-transplantation survival is not compromised.
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