Evidence map›Paper›PMID 39004945›Full record

ArticleBiopolymers2024

Defined folding pattern of poly(rG) supports inherent ability to encode biological information.

Nickolas Kankia, Levan Lomidze, Skylar Stevenson, Karin Musier-Forsyth, Besik Kankia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biopolymers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nickolas KankiaDepartment of Chemistry and Biochemistry, Center for RNA biology, The Ohio State University, Columbus, Ohio, USA.
Levan LomidzeInstitute of Biophysics, Ilia State University, Tbilisi, Georgia.
Skylar StevensonDepartment of Chemistry and Biochemistry, Center for RNA biology, The Ohio State University, Columbus, Ohio, USA.
Karin Musier-ForsythDepartment of Chemistry and Biochemistry, Center for RNA biology, The Ohio State University, Columbus, Ohio, USA.
Besik KankiaDepartment of Chemistry and Biochemistry, Center for RNA biology, The Ohio State University, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-2091-485X

Funding

Ohio State University Mentoring Undergraduate Scholars for Excellence ProgramOhio State University Undergraduate Research Apprenticeship ProgramShota Rustaveli National Science Foundation YS-19-102
6 · The paper itself

Abstract

The RNA World hypothesis posits that RNA can represent a primitive life form by reproducing itself and demonstrating catalytic activity. However, this hypothesis is incapable of addressing several major origin-of-life (OoL) questions. A recently described paradox-free alternative OoL hypothesis, the Quadruplex (G4) World, is based on the ability of poly(dG) to fold into a stable architecture with an unambiguous folding pattern using G-tetrads as building elements. Because of the folding pattern of three G-tetrads and single-G loops, dG

Indexed as

DNAG-QuadruplexesRNAThermodynamicsNucleic Acid ConformationPoly GDNAPoly GRNAinformationprogrammabilityquadruplexthermodynamics

Identifiers

PMID39004945
PMCPMC11579231

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.