Evidence map›Paper›PMID 39004461›Full record

ReviewAdvances in kidney disease and health2024

Membranoproliferative Glomerulonephritis Pattern of Injury.

Samuel Mon-Wei Yu, Margaret Deoliveira, Miriam Chung, Richard Lafayette

Abstract readReview
In one paragraph

Review in Advances in kidney disease and health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Samuel Mon-Wei YuDivision of Nephrology, Mount Sinai Hospital, New York, NY. Electronic address: mon-wei.yu@mountsinai.org.
Margaret DeoliveiraDivision of Nephrology, Mount Sinai Hospital, New York, NY.
Miriam ChungDivision of Nephrology, Mount Sinai Hospital, New York, NY.
Richard LafayetteDivision of Nephrology, Stanford University Medical Center, Stanford, CA.

Funding

Unanticipated roles of C5aR1 Signaling Leading from Acute to Chronic Kidney DiseaseK08DK132501 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Mon-Wei Yu · 2023 to 2026
$734k
NIDDK NIH HHS K08 DK132501
6 · The paper itself

Abstract

Membranoproliferative glomerulonephritis (MPGN) is no longer a disease but a pattern of injury in various diseases. Characterized by electron-dense deposits, mesangial proliferation, and duplication of the glomerular basement membrane, MPGN was previously classified by findings seen by electron microscopy. However, recognizing complement dysfunction in relation to cases with the MPGN pattern of injury substantially changed our view of its pathogenesis. A new classification, including immune complex-mediated and complement-mediated MPGN, has become preferable and has been adopted by international guidelines. Despite these advancements, accurate diagnosis of MPGN remains a clinical challenge, given the pathological and clinical similarities between immune complex-mediated and complement-mediated MPGN. Additional testing, such as molecular and genetic testing, is often necessary. Here, we will summarize our current understanding of the MPGN pattern of injury from a pathology perspective as an introductory article in the following chapters.

Indexed as

Glomerulonephritis, MembranoproliferativeComplement System ProteinsGlomerular Basement MembraneHumansKidney GlomerulusMicroscopy, ElectronComplement System ProteinsComplementsImmune complexMembranoproliferative glomerulonephritis

Identifiers

PMID39004461
PMCPMC11251708

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.