ArticleCell reports2024
Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Risk assessment of avian influenza A(H5N5) virus from the first human case using the ferret model.Journal of virology · 2026Article
- High pathogenicity avian influenza A (H5N1) viruses isolated from poultry and wild birds in Japan during the 2024-2025 season.Microbiology spectrum · 2026Article
- Multiple introductions of highly pathogenic avian influenza viruses into the High Arctic: Svalbard and Jan Mayen, 2022-2025.The Journal of general virology · 2026Article
- Between-species contagion drives HPAI transmission and mass mortality in seabirds.The Journal of animal ecology · 2026Article
- A lethal human H5N5 influenza virus isolate exhibits low pandemic risk traits.bioRxiv : the preprint server for biology · 2026Article
- Population immunity to clade 2.3.4.4b H5N1 is dominated by anti-neuraminidase antibodies.mBio · 2026Article
- Mammary and respiratory infection of sheep with H5Nx clade 2.3.4.4b viruses with milk-mediated transmission to lambs.Science advances · 2026Article
- MF59-adjuvanted A/Astrakhan influenza vaccine induces cross-neutralizing H5N1 antibodies in ferrets against circulating clade 2.3.4.4b viruses.NPJ vaccines · 2026Article
- Review
- Interannual differences in common eider duck exposure to avian influenza viruses at an Arctic colony.Conservation physiology · 2026Article
- Pathogenicity in chickens and ducks of clade 2.3.4.4b H5N6 and H5N3 high pathogenicity avian influenza viruses in South Korea.Frontiers in veterinary science · 2026Article
- Detection of Two High Pathogenicity Avian Influenza Virus (HPAIV) Subtypes, H5N1 and H5N5, in a Mass Mortality Event in Wild Seabirds and Co-Location With Dead Seals.Transboundary and emerging diseases · 2026Article
- Article
- Article
- Highly pathogenic avian influenza virus (H5N5) detected in an Atlantic walrus (Emerging microbes & infections · 2025Article
- Survival of influenza virus H1N1 and murine norovirus in raw milk cheeses.Applied and environmental microbiology · 2025Article
- Impact of naturally occurring hemagglutinin substitutions on antigenicity and fitness of influenza A(H5N1) virus.Npj viruses · 2025Article
- Circumpolar spread of avian influenza H5N1 to southern Indian Ocean islands.Nature communications · 2025Article
- Decoding non-human mammalian adaptive signatures of 2.3.4.4b H5N1 to assess its human adaptive potential.Microbiology spectrum · 2025Article
- Intensive transmission in wild, migratory birds drove rapid geographic dissemination and repeated spillovers of H5N1 into agriculture in North America.bioRxiv : the preprint server for biology · 2025Article
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24 authors.
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Abstract
Highly pathogenic avian influenza (HPAI) viruses have spread at an unprecedented scale, leading to mass mortalities in birds and mammals. In 2023, a transatlantic incursion of HPAI A(H5N5) viruses into North America was detected, followed shortly thereafter by a mammalian detection. As these A(H5N5) viruses were similar to contemporary viruses described in Eurasia, the transatlantic spread of A(H5N5) viruses was most likely facilitated by pelagic seabirds. Some of the Canadian A(H5N5) viruses from birds and mammals possessed the PB2-E627K substitution known to facilitate adaptation to mammals. Ferrets inoculated with A(H5N5) viruses showed rapid, severe disease onset, with some evidence of direct contact transmission. However, these viruses have maintained receptor binding traits of avian influenza viruses and were susceptible to oseltamivir and zanamivir. Understanding the factors influencing the virulence and transmission of A(H5N5) in migratory birds and mammals is critical to minimize impacts on wildlife and public health.
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