Evidence map›Paper›PMID 39003660›Full record

ArticleEndocrine2024

Clinicopathological spectrum, management, and outcome of ectopic parathyroid carcinoma: Experience with 24 cases.

Teng Zhao, Jian Huang, Yuting Wang, Dongxue Zhang, Teng Zhang, Ruigang Lu, Hua Gu, Mulan Jin, Hong Shen, Xing Liu and 4 more

Abstract read
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In one paragraph

Article in Endocrine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Teng Zhao *Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Jian Huang *Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yuting Wang *Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Dongxue ZhangDepartment of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Teng ZhangDepartment of Nuclear Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Ruigang LuDepartment of Ultrasound, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Hua GuDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Mulan JinDepartment of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Hong ShenDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Xing LiuDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Dalin FengDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Jiacheng WangDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Qian WangDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Bojun WeiDepartment of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. weibojun1015@126.com.

Funding

Beijing Municipal Administration of Hospitals Incubating Program PX2023009National Natural Science Foundation of China 82200872
6 · The paper itself

Abstract

purposeEctopic parathyroid carcinoma (EPC) is a rare clinical entity with multiple diagnostic pitfalls, making surgical cures challenging. We assessed the clinicopathological spectrum and outcome of EPCs.

methodsIn this retrospective cohort study, 24 EPCs were identified from 133 PC patients treated at a tertiary referral center. The relationship between clinicopathological findings and locations was analyzed.

resultsThe locations of EPCs were predominantly intrathyroidal (62.5%), followed by 16.7% in the mediastinum, 8.3% in the retropharyngeal space, 8.3% in the carotid sheath, and 4.2% in the upper neck. Intrathyroidal EPC patients experienced higher serum calcium (p = 0.020), a higher rate of vascular invasion (p = 0.040), and a slightly higher incidence of non-R0 initial resection (p = 0.092) than those in other ectopic locations. Intrathyroidal EPC patients also suffered a trend of higher upper aerodigestive tract (UAT) invasion rate (p = 0.070) and higher risks of distant metastasis (p = 0.037) than the other PC patients. The 5-year disease-free survival rate after surgery was slightly compromised at 41.5% in intrathyroidal EPC patients compared with 77.8% among those in other ectopic locations (p = 0.143) and 59.7% among the other PC patients (log-rank = 3.194; p = 0.074), though without statistical significance.

conclusionIntrathyroidal EPC might cause a more biochemically and invasively distinct PC picture compared with other PCs. Special caution should be exercised in the preoperative diagnosis and management of such cases.

Indexed as

Parathyroid NeoplasmsAdultAgedCarcinomaChoristomaFemaleHumansMaleMiddle AgedParathyroid GlandsRetrospective StudiesTreatment OutcomeYoung AdultDistant metastasisEctopicParathyroid carcinomaSurgeryThyroid nodule

Identifiers

PMID39003660

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