ArticleEye (London, England)2024
Inter-zonal epithelial thickness differences for early keratoconus detection using optical coherence tomography.
Article in Eye (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early Detection of Keratoconus: Diagnostic Advances and Their Impact on Visual Outcomes: A Systematic Review.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Comparative Diagnostic Efficacy of Swept-Source OCT and Scheimpflug Imaging in Clinically Unaffected Eyes of Very Asymmetric Ectasia.Ophthalmology science · 2026Article
- Epithelial thickness gradients as a diagnostic biomarker for early-stage keratoconus.International ophthalmology · 2026Article
- [Diagnostic innovations for the early detection and characterization of keratoconus].Die Ophthalmologie · 2026Review
- Influence of Scleral Contact Lenses on Optical Coherence Tomography Parameters in Keratoconus Patients.Diagnostics (Basel, Switzerland) · 2025Article
- Epithelial Mapping Efficacy for Subclinical Keratoconus Identification.American journal of ophthalmology · 2025Article
- Evaluation of indices for the assessment and classification of keratoconus based on optical coherence tomography and Scheimpflug technology.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Strategies for Early Keratoconus Diagnosis: A Narrative Review of Evaluating Affordable and Effective Detection Techniques.Journal of clinical medicine · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop and test a parameter for early keratoconus screening by quantifying the localized epithelial thickness differences in keratoconic eyes.
methodsThe cross-sectional study included 189 eyes of 116 subjects in total: 86 eyes of 54 keratoconus patients with bilateral ectasia and 40 eyes of 20 healthy subjects in the parameter-development dataset and 42 eyes of 21 keratoconus patients with asymmetric ectasia and 21 eyes of 21 healthy subjects in the parameter-validation dataset. Epithelial thickness maps were obtained using anterior segment optical coherence tomography and the inter-zonal epithelial thickness differences were calculated. The developed parameter was tested in keratoconus patients with asymmetric ectasia.
resultsCompared to healthy controls, the inferior-temporal and global inter-zonal epithelial thickness differences were higher not only in eyes with tomographically significant keratoconus (median [interquartile range] of 4.42 [3.13] µm vs. 0.78 [0.42] µm, p < 0.001, and 3.05 [1.51] µm vs. 1.07 [0.26] µm, p < 0.001, respectively), but also in tomographically normal keratoconus fellow eyes (1.36 [0.85] µm vs. 0.78 [0.42] µm, p = 0.005, and 1.31 [0.32] µm vs. 1.07 [0.26] µm, p = 0.01, respectively). The inferior-temporal inter-zonal epithelial thickness differences had an area under the receiver operating characteristic curve (95% confidence interval) of 0.991 (0.972-1) for detecting tomographically significant keratoconus and 0.749 (0.598-0.901) for differentiating between tomographically normal keratoconus fellow eyes and healthy controls.
conclusionsThe inter-zonal epithelial thickness differences are increased in keratoconus fellow eyes which still have a normal Scheimpflug corneal tomography, and therefore may serve as a useful parameter to detect early ectatic changes.
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