ArticleCommunications medicine2024
The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia.
Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Inflammation profiles in Alzheimer's disease relate to cognition and neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Metabolomic levels mediate the link between socioeconomic factors and changes in declarative memory in women with and without HIV.Brain, behavior, & immunity - health · 2026Article
- Cumulative burden of depression and domain-specific cognitive impairment over time in the women's interagency HIV study: A marginal structural model approach.Journal of affective disorders · 2026Article
- DNA methylation age acceleration mediates the relationship between systemic inflammation and cognitive impairment.Epigenomics · 2025Article
- Temporal comorbidity patterns in Alzheimer's disease and vascular dementia: A population-based observational study in UK Biobank.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundExposure to systemic racism is linked to increased dementia burden. To assess systemic inflammation as a potential pathway linking exposure to racism and dementia disparities, we investigated the mediating role of C-reactive protein (CRP), a systemic inflammation marker, and the moderating role of the racialization process in incident dementia.
methodsIn the US Health and Retirement Study (n = 6,908), serum CRP was measured at baseline (2006, 2008 waves). Incident dementia was classified by cognitive tests over a six-year follow-up. Self-reported racialized categories were a proxy for exposure to the racialization process. We decomposed racialized disparities in dementia incidence (non-Hispanic Black and/or Hispanic vs. non-Hispanic white) into 1) the mediated effect of CRP, 2) the moderated portion attributable to the interaction between racialized group membership and CRP, and 3) the controlled direct effect (other pathways through which racism operates).
resultsThe 6-year cumulative incidence of dementia is 12%. Among minoritized participants (i.e., non-Hispanic Black and/or Hispanic), high CRP levels ( ≥ 75
conclusionsMinoritized group membership modifies the relationship between systemic inflammation and incident dementia.
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Registered trials
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