Evidence map›Paper›PMID 39003381›Full record

ArticleAnnals of surgical oncology2024

Longitudinal Increases in Time to Surgery for Patients with Breast Cancer: A National Cohort Study.

Gabriella N Tortorello, Neha Shafique, Luke Keele, Carolyn G Susman, Anushka Dheer, Oluwadamilola M Fayanju, Julia Tchou, John T Miura, Giorgos C Karakousis

Abstract read
In one paragraph

Article in Annals of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gabriella N TortorelloDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA. Gabriella.tortorello@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0002-1836-6612
Neha ShafiqueDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Luke KeeleDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Carolyn G SusmanPerelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Anushka DheerDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Oluwadamilola M FayanjuDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Julia TchouDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
John T MiuraDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Giorgos C KarakousisDepartment of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

Funding

Using Modifiable Risk Factors to Predict Inferior Care and Survival after Breast Cancer Diagnosis: A Novel Approach to Addressing Health DisparitiesK08CA241390 · NCI · UNIVERSITY OF PENNSYLVANIA · PI FAYANJU, OLUWADAMILOLA M. · 2019 to 2023
$1.1M
NCI NIH HHS K08 CA241390
6 · The paper itself

Abstract

backgroundLonger time to surgery (TTS) is associated with worse survival in patients with breast cancer. Whether this association has encouraged more prompt care delivery remains unknown.

methodsThe National Cancer Database was used to identify patients ≥18 years of age diagnosed with clinical stage 0-III breast cancer between 2006 and 2019 for whom surgery was the first mode of treatment. A linear-by-linear test for trend assessed median TTS across the interval. Adjusted linear regression modeling was used to examine TTS trends across patient subgroups.

resultsOverall, 1,435,584 patients met the inclusion criteria. The median age was 63 years (interquartile range [IQR] 53-72), 84.3% of patients were White, 91.1% were non-Hispanic, and 99.2% were female. The median TTS in 2006 was 26 days (IQR 16-39) versus 39 days in 2019 (IQR 27-56) [p < 0.001]. In a multivariable linear regression model, TTS increased significantly, with an annual increase of 0.83 days (95% confidence interval 0.82-0.85; p < 0.001). A consistent, significant increase in TTS was observed on subgroup analyses by surgery type, reconstruction, patient race, hospital type, and disease stage. Black race, Hispanic ethnicity, and having either Medicaid or being uninsured were significantly associated with prolonged TTS, as were mastectomy and reconstructive surgery.

conclusionsDespite evidence that longer TTS is associated with poorer outcomes in patients with breast cancer, TTS has steadily increased, which may be particularly detrimental to marginalized patients. Further studies are needed to ensure the delivery of timely care to all patients.

Indexed as

Breast NeoplasmsMastectomyTime-to-TreatmentAdultAgedCohort StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPrognosisSurvival RateUnited StatesBreast cancerTime to surgeryTime to treatment

Identifiers

PMID39003381
PMCPMC11413055

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.