Evidence map›Paper›PMID 39003347›Full record

Trial reportEuropean journal of clinical nutrition2024

The addition of mycoprotein to a mixed-meal impacts postprandial glucose kinetics without altering blood glucose concentrations: a randomised controlled trial.

Gráinne Whelehan, Sam West, Doaa R Abdelrahman, Andrew J Murton, Tim J A Finnigan, Benjamin T Wall, Francis B Stephens

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04084639 (To Determine the Effects of Mycoprotein Consumption on Glucose Absorption in Healthy Participants), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04084639 nacompletednot on this map

To Determine the Effects of Mycoprotein Consumption on Glucose Absorption in Healthy Participants

TypeinterventionalSponsorUniversity of ExeterRan2019 to 2019Enrolled15ConditionsHealthyArmsMycoprotein Ingestion
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gráinne WhelehanDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK.ORCID http://orcid.org/0000-0003-1391-4349
Sam WestDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK.
Doaa R AbdelrahmanDepartment of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Andrew J MurtonDepartment of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Tim J A FinniganNew Era Foods, Hutton Rudby, Yarm, TS15 0JZ, UK.
Benjamin T WallDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK.
Francis B StephensDepartment of Public Health and Sport Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, EX1 2LU, UK. f.b.stephens@exeter.ac.uk.ORCID http://orcid.org/0000-0001-6312-5351

Funding

UTMB OAIC Research Education Component (REC)P30AG024832 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI JAMES S. GOODWIN, MD, MELISSA M. MORROW · 2005 to 2026
$26.7M
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) P30-AG024832
6 · The paper itself

Abstract

backgroundMycoprotein is a high-fibre food previously shown to reduce postprandial glucose concentrations when ingested within a mixed-meal. We applied a dual stable isotope tracer approach to determine whether this is due to a reduced rate of appearance of glucose, in participants of ranging BMI.

methodsTwenty-four adults (F = 8, BMI 30 ± 6 kg·m

resultsDrink ingestion increased blood glucose and serum insulin concentrations (P < 0.05) and were comparable between conditions (P > 0.05). Both RaT and RdT were higher with MYC compared with CON over 6 h (mean 6 h glucose appearance and disappearance increased by 5 and 9%, respectively, P < 0.05). RaEx was not affected by MYC ingestion over 6 h (P > 0.05). The mean contribution of EGP to total glucose appearance was 15% greater with MYC, with a trend towards significance (P = 0.05). There was no relationship between BMI and the response to MYC ingestion for any of the variables (P < 0.05).

conclusionThe ingestion of mycoprotein within a mixed-meal impacted postprandial glucose kinetics, but not blood glucose or serum insulin concentrations, in individuals of ranging BMI. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE: This trial was registered at clinicaltrials.gov as NCT04084639 and can be accessed at https://clinicaltrials.gov/ct2/show/NCT04084639 .

Indexed as

Blood GlucoseCross-Over StudiesPostprandial PeriodAdultDietary FiberDouble-Blind MethodFemaleHumansInsulinKineticsMaleMealsMiddle AgedYoung AdultBlood GlucoseDietary FiberInsulin

Identifiers

PMID39003347
PMCPMC11368804

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.