Evidence map›Paper›PMID 39003234›Full record

ArticleAge and ageing2024

Stimulating leisure-time activities and the risk of dementia: a multi-cohort study.

Katriina Heikkilä, Jaana Pentti, Serhiy Dekhtyar, Jenni Ervasti, Laura Fratiglioni, Tommi Härkänen, Mika Kivimäki, Seppo Koskinen, Tiia Ngandu, Säde Stenlund and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Age and ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Katriina HeikkiläDepartment of Public Health, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.ORCID 0000-0001-6269-6881
Jaana PenttiDepartment of Public Health, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.
Serhiy DekhtyarAging Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 171 65 Solna Stockholm, Sweden.
Jenni ErvastiFinnish Institute of Occupational Health, PB 40, 00032 Helsinki, Finland.
Laura FratiglioniAging Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, 171 65 Solna Stockholm, Sweden.
Tommi HärkänenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland.
Mika KivimäkiClinicum, Faculty of Medicine, University of Helsinki, Tukholmankatu 8 B, 00014 Helsinki, Finland.ORCID 0000-0002-4699-5627
Seppo KoskinenDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland.
Tiia NganduDepartment of Public Health and Welfare, Finnish Institute for Health and Welfare, Mannerheimintie 166, 00300 Helsinki, Finland.ORCID 0000-0002-3698-2021
Säde StenlundDepartment of Public Health, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.
Sakari SuominenDepartment of Public Health, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.
Jussi VahteraDepartment of Public Health, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.
Suvi RovioDepartment of Public Health, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.
Sari StenholmDepartment of Public Health, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520 Turku, Finland.

Funding

Education, socioeconomic status and Aging: transitions from multimorbidity to functional limitations and mortalityR01AG056477 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2018 to 2022
$2.8M
Academy of Finland 321409Juho Vainio FoundationNIA NIH HHS R01 AG062553Research Council Finland 332030Research Council Finland 350426Signe and Ane Gyllenberg FoundationSwedish Ministry of Health and Social AffairsSwedish Research Council 2011-6,243Swedish Research Council for Health, Working Life and Welfare 2016-07175UK Medical Research Council S011676US National Institute on Aging R01AG056477Wellcome Trust 221854/Z/20/Z
6 · The paper itself

Abstract

backgroundStimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with the risk of dementia across up to two decades' follow-up.

methodsWe used data from five prospective cohort studies from Finland and Sweden. Mental, social, outdoor, consumptive and physical leisure-time activities were self-reported. Incident dementia was ascertained from clinical diagnoses or healthcare and death registers. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

resultsOf the 33 263 dementia-free individuals aged ≥50 years at baseline, 1408 had dementia during a mean follow-up of 7.0 years. Active participation in mental (HR: 0.52, 95% CI: 0.41 to 0.65), social (HR: 0.56 95% CI: 0.46 to 0.72), outdoor (HR: 0.70, 95% CI: 0.58 to 0.85), consumptive (HR: 0.67, 95% CI: 0.53 to 0.94) and physical (HR: 0.62, 95% CI: 0.51 to 0.75) activity, as well as variety (HR: 0.54, 95% CI: 0.43 to 0.68) and the overall frequency of activity (HR: 0.41, 95% CI: 0.34 to 0.49) were associated with a reduced risk of dementia in <10 years' follow-up. In ≥10 years' follow-up all associations attenuated toward the null.

conclusionStimulating leisure-time activities are associated with a reduced risk of dementia in short-term but not long-term follow-up. These findings may reflect a reduction in leisure-time activity following preclinical dementia or dilution of the association over time.

Indexed as

DementiaLeisure ActivitiesAgedFemaleFinlandHumansIncidenceMaleMiddle AgedProspective StudiesProtective FactorsRisk AssessmentRisk FactorsSwedenTime Factorsactivitycognitivedementiameta-analysisolder peopleprospective study

Identifiers

PMID39003234
PMCPMC11246193

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.