Evidence map›Paper›PMID 39003166›Full record

ArticleClinical radiology2024

The utility of dynamic contrast-enhanced intranodal magnetic resonance lymphangiography (MRL) in the investigation of primary lymphatic anomalies.

L A Ratnam, M Mills, A Wale, L R Howroyd, M Itkin, F A Howe, K Gordon, S Mansour, P Ostergaard, P S Mortimer

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In one paragraph

Article in Clinical radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

L A RatnamDepartment of Radiology, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK; Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK. Electronic address: lakshmi.ratnam@stgeorges.nhs.uk.
M MillsMolecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.
A WaleDepartment of Radiology, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK; Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.
L R HowroydDepartment of Radiology, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK; Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.
M ItkinDepartment of Radiology, University of Pennsylvania Health System, Philadelphia, USA.
F A HoweMolecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.
K GordonMolecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK; Dermatology and Lymphovascular Medicine, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
S MansourMolecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK; South West Thames Centre for Genomics, St George's University Hospitals NHS Foundation Trust, London, UK. Electronic address: smansour@sgul.ac.uk.
P OstergaardMolecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK.
P S MortimerMolecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, UK; Dermatology and Lymphovascular Medicine, St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.

Funding

British Heart Foundation (BHF) RG/17/7/33217Medical Research Council (MRC) MR/P011543/1
6 · The paper itself

Abstract

aimThe aim of this study was to describe the technique of DCMRL to identify central lymphatic abnormalities in patients with primary lymphatic anomalies and discuss utility of the findings. MATERIALS AND

methodsTwenty-eight patients with primary lymphatic abnormalities underwent dynamic magnetic resonance imaging (MRI) following injection of gadolinium directly into inguinal lymph nodes at a tertiary lymphovascular referral center.

resultsTechnical success was achieved in 23 patients (82.1%). Pathological imaging findings included obstructed, hypoplastic, or absent lymphatic channels with collateralization/rerouting or reflux of flow, lymphangiectasia, lymphatic pseudoaneurysms, and lymph leaks. Protocol modifications for improved imaging are highlighted including technical aspects of lymph node injection, image acquisition and MRI parameters. In two patients, imaging findings warranted embolization of the abnormal lymphatic channels with subsequent symptomatic improvement.

conclusionDCMRL has been shown to be a safe, reproducible technique in patients with primary lymphatic anomalies enabling imaging of the central lymphatic system.

Indexed as

Contrast MediaLymphatic AbnormalitiesLymphographyMagnetic Resonance ImagingAdolescentAdultAgedChildChild, PreschoolFemaleHumansInfantLymph NodesMaleMiddle AgedYoung AdultContrast Media

Identifiers

PMID39003166
PMCPMC11584322

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