Evidence map›Paper›PMID 39002671›Full record

ArticleThe Journal of biological chemistry2024

Structural basis of binding the unique N-terminal domain of microtubule-associated protein 2c to proteins regulating kinases of signaling pathways.

Viktor Bartošík, Jitka Plucarová, Alice Laníková, Zuzana Janáčková, Petr Padrta, Séverine Jansen, Vojtěch Vařečka, Tobias Gruber, Stephan M Feller, Lukáš Žídek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Viktor BartošíkNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic.
Jitka PlucarováNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Alice LaníkováNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Zuzana JanáčkováNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic.
Petr PadrtaNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Séverine JansenNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
Vojtěch VařečkaInstitute of Chemistry, Faculty of Science, Masaryk University, Brno, Czech Republic.
Tobias GruberInstitute of Molecular Medicine, Tumor Biology, Martin-Luther-University of Halle-Wittenberg, Germany; Institute of Physics, Biophysics, Martin-Luther-University of Halle-Wittenberg, Germany.
Stephan M FellerInstitute of Molecular Medicine, Tumor Biology, Martin-Luther-University of Halle-Wittenberg, Germany.
Lukáš ŽídekNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic. Electronic address: lzidek@chemi.muni.cz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoforms of microtubule-associated protein 2 (MAP2) differ from their homolog Tau in the sequence and interactions of the N-terminal region. Binding of the N-terminal region of MAP2c (N-MAP2c) to the dimerization/docking domains of the regulatory subunit RIIα of cAMP-dependent protein kinase (RIIDD

Indexed as

GRB2 Adaptor ProteinMicrotubule-Associated ProteinsProtein BindingAnimalsHumansProtein DomainsProto-Oncogene Proteins c-fynSignal Transductionsrc Homology DomainsGRB2 Adaptor ProteinGRB2 protein, humanMicrotubule-Associated ProteinsProto-Oncogene Proteins c-fynA-kinase anchoring protein (AKAP)growth factor receptor-bound protein 2 (GRB2)microtubule associated protein (MAP) 2nuclear magnetic resonance (NMR)protein kinase A (PKA)

Identifiers

PMID39002671
PMCPMC11367651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.