Evidence map›Paper›PMID 39002624›Full record

Observational studyContraception2024

The influence of lifestyle factors on serum etonogestrel concentrations among contraceptive implant users.

Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Contraception, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03092037 (Pharmacogenomics of Contraception), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03092037 completednot on this map

Pharmacogenomics of Contraception: Genetic Variants and Etonogestrel Pharmacokinetics

TypeobservationalSponsorUniversity of Colorado, DenverRan2017 to 2022Enrolled900ConditionsContraceptionArmsBlood draw
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aaron LazorwitzUniversity of Colorado Anschutz Medical Campus, Department of Obstetrics and Gynecology, Division of Family Planning, Aurora, CO, USA. Electronic address: aaron.lazorwitz@yale.edu.
Jeanelle SheederUniversity of Colorado Anschutz Medical Campus, Department of Obstetrics and Gynecology, Division of Family Planning, Aurora, CO, USA.
Stephanie TealUniversity Hospitals Cleveland Medical Center and Case Western Reserve University, Department of Obstetrics and Gynecology, Cleveland, OH, USA.

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
COLORADO WRHR CAREER DEVELOPMENT CENTERK12HD001271 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Saketh R Guntupalli · 1999 to 2026
$8.9M
Influence of genetic variants on steroid hormone metabolism and progestin-related side effects in contraceptive implant usersR03HD101551 · NICHD · UNIVERSITY OF COLORADO DENVER · PI LAZORWITZ, AARON · 2021 to 2022
$156k
NCATS NIH HHS UL1 TR001082NICHD NIH HHS K12 HD001271NICHD NIH HHS R03 HD101551
6 · The paper itself

Abstract

objectiveTo evaluate how diet, exercise, and substance use influence serum etonogestrel concentrations among contraceptive implant users. STUDY

designWe conducted a cross-sectional analysis of healthy, reproductive-age etonogestrel implant users. We assessed participants' current diet, exercise, and substance (alcohol, tobacco, marijuana) use habits while simultaneously measuring serum etonogestrel concentrations. We used linear modeling to test for associations between survey responses and etonogestrel concentrations.

resultsAmong 115 participants, exercise habits and substance use had no significant associations with etonogestrel concentrations, while increased caloric intake demonstrated inconsistent associations.

conclusionThe lifestyle factors of diet, exercise, and substance use do not influence steady-state pharmacokinetics among contraceptive implant users. CLINICAL

trial registrationClinicaltrials.gov, NCT03092037.

Indexed as

Contraceptive Agents, FemaleDesogestrelExerciseLife StyleAdolescentAdultCross-Sectional StudiesDietDrug ImplantsFemaleHumansYoung AdultContraceptive Agents, FemaleDesogestrelDrug ImplantsetonogestrelContraceptive implantDietEtonogestrelExerciseLifestyleMarijuana

Identifiers

PMID39002624
PMCPMC11588555

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.