Evidence map›Paper›PMID 39002532›Full record

ArticleJournal of psychiatric research2024

Sex moderates the effect of anhedonia on parietal alpha asymmetry.

Resh S Gupta, Gregory A Light, Alan N Simmons, Katia M Harlé, Daniel M Stout

Abstract read
In one paragraph

Article in Journal of psychiatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Resh S GuptaDepartment of Psychological & Brain Sciences, Washington University in St. Louis, St. Louis, MO, 63130, USA. Electronic address: rsgupta@wustl.edu.
Gregory A LightDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA; Desert Pacific Mental Illness Research Education and Clinical Center, La Jolla, CA, USA.
Alan N SimmonsDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161, USA.
Katia M HarléDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161, USA.
Daniel M StoutDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA; Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Neuro-computational predictors of treatment responsiveness in trauma-exposed Veterans.I01CX002456 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HARLE, KATIA · 2023 to 2025
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The Neurocomputational mechanisms of anhedonia and their role in predicting alcohol use and treatment responsiveness in Veterans with Alcohol Use Disorder"I01CX002655 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI HARLE, KATIA · 2024 to 2025
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CSRD VA I01 CX002456CSRD VA I01 CX002655CSRD VA IK2 CX001861NCATS NIH HHS UL1 TR001442
6 · The paper itself

Abstract

Anhedonia, a transdiagnostic symptom present in many neuropsychiatric disorders, differs in males and females. Parietal EEG alpha asymmetry is associated with reduced arousal and low positive emotionality, and is, therefore, a promising neurophysiologic biomarker of anhedonia. To date, however, no prior studies have determined whether this measure captures sex differences in anhedonic expression. This preliminary study (N = 36) investigated whether anhedonia severity is associated with EEG resting-state parietal alpha asymmetry in adults and whether sex moderates this relationship. Results showed that there was a significant moderating effect of sex such that, only for females, higher levels of anhedonia were associated with increased parietal alpha asymmetry. These findings suggest that parietal alpha asymmetry is a promising biomarker of anhedonia severity in female adults and reinforces the need to account for sex differences in future research.

Indexed as

Alpha RhythmAnhedoniaParietal LobeSex CharacteristicsAdolescentAdultElectroencephalographyFemaleFunctional LateralityHumansMalePsychiatric Status Rating ScalesYoung AdultAnhedoniaEEGParietal alpha asymmetrySexual dimorphism

Identifiers

PMID39002532
PMCPMC11816936

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.