Evidence map›Paper›PMID 39002091›Full record

ReviewNeurochemical research2024

MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer's Disease.

Jian-Sheng Luo, Wen-Hu Zhai, Ling-Ling Ding, Xian-Jie Zhang, Jia Han, Jia-Qi Ning, Xue-Meng Chen, Wen-Cai Jiang, Ru-Yu Yan, Meng-Jie Chen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurochemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jian-Sheng LuoDepartment of Anesthesiology, Deyang People's Hospital, Deyang, 618000, China.
Wen-Hu ZhaiDepartment of Anesthesiology, Deyang People's Hospital, Deyang, 618000, China.
Ling-Ling DingDepartment of Anesthesiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China. dinglingling301@126.com.
Xian-Jie ZhangDepartment of Anesthesiology, Deyang People's Hospital, Deyang, 618000, China.
Jia HanDepartment of Anesthesiology, Deyang People's Hospital, Deyang, 618000, China.
Jia-Qi NingDepartment of Anesthesiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Xue-Meng ChenDepartment of Anesthesiology, Deyang People's Hospital, Deyang, 618000, China.
Wen-Cai JiangDepartment of Anesthesiology, Deyang People's Hospital, Deyang, 618000, China.
Ru-Yu YanDepartment of Anesthesiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Meng-Jie ChenDepartment of Anesthesiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.

Funding

Capital's Funds for Health Improvement and Research 2022-2-2232National Natural Science Foundation of China 82374580Science and Technology Development Fund of Beijing Hospital of Traditional Chinese Medicine, Capital Medical University LYYB202216
6 · The paper itself

Abstract

Alzheimer's disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting a substantial challenge to global public health. The mitochondrial-associated membrane (MAMs) functions as a crucial center for signal transduction and material transport between mitochondria and the endoplasmic reticulum, playing a pivotal role in various pathological mechanisms of AD. The dysregulation of mitochondrial quality control systems is considered a fundamental factor in the development of AD, leading to mitochondrial dysfunction and subsequent neurodegenerative events. Recent studies have emphasized the role of MAMs in regulating mitochondrial quality control. This review will delve into the molecular mechanisms underlying the imbalance in mitochondrial quality control in AD and provide a comprehensive overview of the role of MAMs in regulating mitochondrial quality control.

Indexed as

Alzheimer DiseaseMitochondriaMitochondrial MembranesAnimalsEndoplasmic ReticulumHumansAlzheimer’s diseaseMAMsMitochondrial quality control

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.