Evidence map›Paper›PMID 39002019›Full record

ArticleMolecular biology reports2024

Chlorogenic acid mitigates potassium dichromate-induced acute hepato-nephrotoxicity by attenuating the NF-κB signalling pathway.

Semiha Orhan, Ruhi Turkmen, Hasan Huseyin Demirel, Murat Sırrı Akosman, Turkan Turkmen, Fatma Fırat

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Semiha OrhanIntensive Care Unit Afyonkarahisar, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Ruhi TurkmenDepartment of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey. ruhiturkmen@aku.edu.tr.ORCID http://orcid.org/0000-0003-4726-3900
Hasan Huseyin DemirelDepartment of Laboratory Research and Veterinary Medicine, Afyon Kocatepe University, Bayat Vocational School, Afyonkarahisar, Turkey.
Murat Sırrı AkosmanDepartment of Anatomy, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
Turkan TurkmenFaculty of Medical Microbiology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.
Fatma FıratDepartment of Histology and Embryology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHexavalent chromium (CrVI) is known to be a potentially hepatotoxic and nephrotoxic contaminant in humans and other animals, whose toxicity is associated with oxidative stress and inflammation. The aim of this study was to evaluate the potential protective effect of chlorogenic acid (CGA), which has known anti-inflammatory and antioxidant effects, on potassium dichromate (PDC)-induced acute hepatotoxicity and nephrotoxicity in rats. METHODS AND

resultsThirty-six Wistar albino rats were treated with CGA (10, 20, or 40 mg/kg, intraperitoneally) and/or PDC (15 mg/kg/day, intraperitoneally) as a single dose. Serum, liver, and kidney tissues were examined biochemically, histopathologically, and immunohistochemically. Compared to the control group, a significant increase in interleukin-6 (IL-6) levels and a significant decrease in serum and renal reduced glutathione (GSH) levels, liver catalase (CAT), tumour necrosis factor-alpha (TNF-α), and interleukin 1β (IL-1β) levels were observed in the PDC group. The administration of PDC led to histopathological and immunohistochemical changes in rat liver and kidney tissues. With the administration of CGA, especially at the 10 mg/kg dosage, the above-mentioned parameters approached normal levels.

conclusionsCGA had antioxidant and anti-inflammatory effects that alleviated PDC-induced acute hepato- and nephrotoxicity.

Indexed as

AntioxidantsChlorogenic AcidKidneyLiverNF-kappa BOxidative StressPotassium DichromateRats, WistarSignal TransductionAnimalsCatalaseChemical and Drug Induced Liver InjuryGlutathioneInterleukin-1betaInterleukin-6MaleAntioxidantsCatalaseChlorogenic AcidGlutathioneInterleukin-1betaInterleukin-6NF-kappa BPotassium DichromateTumor Necrosis Factor-alphaChlorogenic acidHepatotoxicityHistopathology/immunohistochemistryInflammationOxidative stressPotassium dichromate

Identifiers

PMID39002019

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.