Evidence map›Paper›PMID 39001916›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2024

Patterns of recurrence in patients with CRSwNP who underwent complete FESS.

Lirit Levi, Shany Havazelet, Yonatan Reuven, Aiman Elmograbi, Samih Badir, Yohai Shraga, Gabriel Nakache, Ethan Soudry

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lirit LeviDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel. liritcoh@gmail.com.ORCID http://orcid.org/0000-0002-7075-8752
Shany HavazeletDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel.
Yonatan ReuvenDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel.
Aiman ElmograbiDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel.
Samih BadirDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel.
Yohai ShragaDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel.
Gabriel NakacheDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel.
Ethan SoudryDepartment of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Jabotinski St, Petah Tikva, 49100, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo analyze recurrence patterns of chronic sinusitis with nasal polyposis (CRSwNP) in patients who underwent complete FESS and identify predisposing factors for different patterns of recurrence.

methodsRetrospective analysis of patients with CRSwNP who underwent complete FESS at our tertiary medical center. Recurrence patterns were classified into edema, polyp and normal endoscopy, as well as into early (within 6 months) and late recurrence. Statistical analysis to identify risk factors for recurrence included univariate, multivariate logistic regression and cox regression models.

results114 patients were included with an average follow-up of 27 months. 91% were categorized as type-2 inflammation. Recurrence was observed in 65.8% of patients within a mean of 12.9 months. 46.7% had polyp recurrence while 53.3% had edema recurrence. Early recurrence was observed in 41%. Serum eosinophilia > 500 cells/uL was found to be significantly associated with recurrence (RR = 1.62, p-value = 0.046), and particularly with polyp recurrence (RR = 3.9, p-value = 0.001). No predictive factors for early recurrence were identified. Edema recurrence was managed with intranasal corticosteroids while polyp recurrence required systemic therapy including biologic therapy.

conclusionsIn this study, two thirds of patients experienced post operative recurrence, either mucosal edema or nasal polyps, with similar frequency during an average follow up of over 2 years. Early recurrence was noted in 41% of recurrent cases. Serum eosinophils > 500 cells/uL was the only risk factor for recurrence on multivariate analysis, more accurate markers are needed for improved treatment allocation to CRSwNP patients.

Indexed as

EndoscopyNasal PolypsRecurrenceRhinitisSinusitisAdultAgedChronic DiseaseEdemaEosinophiliaFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesChronic rhinosinusitisFESSNasal polyposisParanasal sinusesPost-operativeRecurrence

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