Evidence map›Paper›PMID 39001731›Full record

ArticleJACC. Cardiovascular imaging2024

Prognostic Value of Left Ventricular

Olivier F Clerc, Yesh Datar, Sarah A M Cuddy, Giada Bianchi, Alexandra Taylor, Dominik C Benz, Matthew Robertson, Marie Foley Kijewski, Michael Jerosch-Herold, Raymond Y Kwong and 5 more

Abstract read
In one paragraph

Article in JACC. Cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Imaging Advances in Light Chain Amyloidosis.Diagnostics (Basel, Switzerland) · 2026
    Review
  5. Head-to-head comparison ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  6. Prognostic parameters and detection of cardiac amyloidosis with hybridEuropean journal of nuclear medicine and molecular imaging · 2026
    Observational
  7. Review
  8. Review
  9. Current cardiology reports · 2025
    Review
  10. Cardiac amyloidosis: Innovations in diagnosis and treatment.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Olivier F ClercDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Yesh DatarDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sarah A M CuddyCardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; CV Imaging Program, Cardiovascular Division and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Giada BianchiCardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Alexandra TaylorDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Dominik C BenzDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Matthew RobertsonCV Imaging Program, Cardiovascular Division and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Marie Foley KijewskiDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Michael Jerosch-HeroldCV Imaging Program, Cardiovascular Division and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Raymond Y KwongCV Imaging Program, Cardiovascular Division and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Frederick L RubergAmyloidosis Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA; Section of Cardiovascular Medicine, Department of Medicine, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Ronglih LiaoAmyloidosis Program, Stanford University, Stanford, California, USA.
Marcelo F Di CarliDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA; CV Imaging Program, Cardiovascular Division and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Rodney H FalkCardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Sharmila DorbalaDivision of Nuclear Medicine, Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA; Cardiac Amyloidosis Program, Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; CV Imaging Program, Cardiovascular Division and Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: sdorbala@bwh.harvard.edu.

Funding

Molecular Imaging of Primary Amyloid CardiomyopathyR01HL130563 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA, FALK, RODNEY H · 2016 to 2019
$3.3M
Role of Abcg2/Bcrp1 in Cardiac Side Population CellsR01HL093148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIAO, RONGLIH · 2008 to 2012
$2.1M
Mentoring Patient Oriented Research in Innovative Imaging and High-dimensional Data Approaches to Improve Outcomes in Cardiac AmyloidosisK24HL157648 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DORBALA, SHARMILA · 2021 to 2025
$612k
NHLBI NIH HHS K24 HL157648NHLBI NIH HHS R01 HL093148NHLBI NIH HHS R01 HL130563
6 · The paper itself

Abstract

backgroundPositron emission tomography/computed tomography (PET/CT) with

objectivesThe authors' aim was to evaluate the prognostic value of LV amyloid burden quantified by

methodsA total of 81 participants with newly diagnosed AL amyloidosis underwent

resultsAmong participants (median age, 61 years; 57% males), 36% experienced MACE, increasing from 7% to 63% across tertiles of LV amyloid burden (P < 0.001). LV amyloid burden was associated with MACE (HR: 1.46; 95% CI: 1.16-1.83; P = 0.001). However, this association became nonsignificant when adjusted for Mayo stage. In mediation analysis, the association between LV amyloid burden and MACE was mediated by NT-proBNP (P < 0.001), a marker of cardiomyocyte stretch and heart failure, and a component of Mayo stage.

conclusionsIn this first study to link cardiac

Indexed as

Aniline CompoundsEthylene GlycolsImmunoglobulin Light-chain AmyloidosisNatriuretic Peptide, BrainPeptide FragmentsPositron Emission Tomography Computed TomographyPredictive Value of TestsRadiopharmaceuticalsAgedBiomarkersCardiomyopathiesFemaleHeart FailureHeart TransplantationHeart VentriclesHumansAniline CompoundsBiomarkersEthylene GlycolsflorbetapirImmunoglobulin Light ChainsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Radiopharmaceuticals(18)F-florbetapiradverse outcomescardiomyopathylight-chain (AL) amyloidosismediation analysispositron emission tomography (PET)

Identifiers

PMID39001731
PMCPMC11975406

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.