Evidence map›Paper›PMID 39001704›Full record

ArticleJournal of extracellular vesicles2024

Characterisation of LPS+ bacterial extracellular vesicles along the gut-hepatic portal vein-liver axis.

Heetanshi Jain, Ashish Kumar, Sameh Almousa, Shalini Mishra, Kendall L Langsten, Susy Kim, Mitu Sharma, Yixin Su, Sangeeta Singh, Bethany A Kerr and 1 more

Abstract read
In one paragraph

Article in Journal of extracellular vesicles, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Heetanshi JainDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Ashish KumarDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sameh AlmousaDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Shalini MishraDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Kendall L LangstenDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Susy KimDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Mitu SharmaDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Yixin SuDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sangeeta SinghDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Bethany A KerrDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Gagan DeepDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0003-4445-8796

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Laboratory Animal & Comparative Medicine TrainingT32OD010957 · OD · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI J. MARK CLINE · 2012 to 2026
$4.3M
Exosome Mediated Alterations in Cellular Metabolism in the Pathogenesis and Progression of Alzheimer's DiseaseR01AG061805 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MOLINA, ANTHONY J · 2018 to 2022
$3.5M
Multi-Ethnic Study of Atherosclerosis- Cellular Exosomes in Neurodegeneration and Dementia (MESA-CEND)RF1AG068629 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN, HUGHES, TIMOTHY M. · 2021 to 2022
$2.4M
A unique exosome-based approach to identify novel biomarkers for Alzheimer's diseaseR21AG075611 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DEEP, GAGAN · 2022 to 2022
$426k
National Institute of Health 1R21 AG075611National Institute of Health 1RF1AG068629NCI NIH HHS P30 CA012197NIA NIH HHS R01 AG061805NIA NIH HHS R21 AG075611NIA NIH HHS RF1 AG068629NIH HHS T32 OD010957
6 · The paper itself

Abstract

Gut microbiome dysbiosis is a major contributing factor to several pathological conditions. However, the mechanistic understanding of the communication between gut microbiota and extra-intestinal organs remains largely elusive. Extracellular vesicles (EVs), secreted by almost every form of life, including bacteria, could play a critical role in this inter-kingdom crosstalk and are the focus of present study. Here, we present a novel approach for isolating lipopolysaccharide (LPS)+ bacterial extracellular vesicles (bEV

Indexed as

Extracellular VesiclesGastrointestinal MicrobiomeLipopolysaccharidesLiverPortal VeinAnimalsBacteriaDysbiosisFecesMaleMiceMice, Inbred C57BLObesityToll-Like Receptor 4LipopolysaccharidesToll-Like Receptor 4bacterial extracellular vesiclesdysbiosisgut microbiomeinflammationlipopolysaccharide

Identifiers

PMID39001704
PMCPMC11245684

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.