Evidence map›Paper›PMID 39001542›Full record

ArticleCancers2024

Lack of Clinically Significant Relationships of Age or Body Mass Index with Merkel Cell Carcinoma Immunotherapy Outcomes.

Rian Alam, Xinyi Fan, Daniel S Hippe, Lisa M Tachiki, Emily Gong, Emily Huynh, Paul Nghiem, Song Youn Park

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rian AlamDepartment of Dermatology, University of Washington, Seattle, WA 98109, USA.
Xinyi FanFred Hutchinson Cancer Center, Clinical Research Division, Seattle, WA 98109, USA.
Daniel S HippeFred Hutchinson Cancer Center, Clinical Research Division, Seattle, WA 98109, USA.ORCID 0000-0003-2427-4404
Lisa M TachikiFred Hutchinson Cancer Center, Clinical Research Division, Seattle, WA 98109, USA.
Emily GongDepartment of Dermatology, University of Washington, Seattle, WA 98109, USA.
Emily HuynhDepartment of Dermatology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0003-2894-644X
Paul NghiemDepartment of Dermatology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0003-2784-963X
Song Youn ParkDepartment of Dermatology, University of Washington, Seattle, WA 98109, USA.ORCID 0000-0003-4366-1821

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
Understand & overcome resistance to PD-1P01CA225517 · NCI · UNIVERSITY OF WASHINGTON · PI Cecilia C Yeung · 2019 to 2026
$22.7M
NCI NIH HHS P01 CA225517NCI NIH HHS P30 CA015704Prostate Cancer Foundation Kelsey Dickson Team Science Courage Research AwardUniversity of Washington MCC Gift Fund
6 · The paper itself

Abstract

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with a high risk of metastasis. The development of anti-PD-1/PD-L1 immunotherapy has improved outcomes for advanced MCC, yet about 50% of such patients do not achieve durable responses. This study analyzed the effects of age and body mass index (BMI) on immunotherapy response in 183 advanced MCC patients from a single-center longitudinal database. Using Fine-Gray or Cox regression models, treatment response, progression-free survival (PFS), MCC-specific survival, and overall survival (OS) were evaluated. Age showed a significant non-linear relationship with treatment response (

Indexed as

agebody mass indeximmunotherapyMerkel cell carcinoma

Identifiers

PMID39001542
PMCPMC11240446

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.