Evidence map›Paper›PMID 39001486›Full record

ArticleCancers2024

C-Reactive Protein Kinetic as a Potential Predictive and Prognostic Factor during Treatment with Checkpoint Inhibitors in R/M-HNSCC.

Frederic Jungbauer, Claudia Scherl, Nicole Rotter, Annette Affolter, Anne Lammert, Elena Seiz, Margot Thiaucourt, Lena Huber

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Frederic JungbauerDepartment of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-4512-0263
Claudia ScherlDepartment of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-9651-0974
Nicole RotterDepartment of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.
Annette AffolterDepartment of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.
Anne LammertDepartment of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.
Elena SeizDepartment of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.
Margot ThiaucourtMVZ Labor Dr. Limbach & Kollegen, 69126 Heidelberg, Germany.
Lena HuberDepartment of Otorhinolaryngology, Head- and Neck-Surgery, University Medical Centre Mannheim, Medical Faculty Mannheim of Heidelberg University, 68167 Mannheim, Germany.ORCID 0000-0002-0252-4911

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction The kinetic of C-reactive protein (CRP) in the early phase of therapy with checkpoint inhibitors (CPI) and its prognostic value has already been investigated in several tumor entities. In particular, flare dynamics have been described as a positive prognostic parameter. The aim of this retrospective study is to examine the extent to which such an application can also be transferred to patients with recurrent or metastatic squamous cell carcinoma of the head and neck region (R/M-HNSCC). Material and Methods All patients treated with CPI for R/M-HNSCC at our clinic between 2018 and 2023 were included (

Indexed as

checkpoint inhibitors (CPI)C-reactive protein (CRP)flare dynamichead and neck squamous cell carcinoma (HNSCC)PD-1prognostic factor

Identifiers

PMID39001486
PMCPMC11240492

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.