Evidence map›Paper›PMID 39001479›Full record

ArticleCancers2024

The Prospective Association between Early Life Growth and Breast Density in Young Adult Women.

Rachel Lloyd, Sarah Pirikahu, Jane Walter, Gemma Cadby, Nicole Warrington, Dilukshi Perera, Martha Hickey, Christobel Saunders, Michael Hackmann, David D Sampson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rachel LloydGenetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0003-2751-6894
Sarah PirikahuGenetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.
Jane WalterUniversity Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-8466-6712
Gemma CadbyGenetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.
Nicole WarringtonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4067, Australia.
Dilukshi PereraGenetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.
Martha HickeyDepartment of Obstetrics and Gynaecology, University of Melbourne and the Royal Women's Hospital, Melbourne, VIC 3052, Australia.
Christobel SaundersDepartment of Surgery, The University of Melbourne, Parkville, VIC 3052, Australia.
Michael HackmannSchool of Human Sciences, The University of Western Australia, Crawley, WA 6009, Australia.ORCID 0000-0003-3940-0397
David D SampsonSchool of Computer Science and Electronic Engineering, The University of Surrey, Guildford, Surrey GU2 7XH, UK.ORCID 0000-0001-6724-3873
John ShepherdEpidemiology and Population Sciences in the Pacific Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.ORCID 0000-0003-2280-2541
Lothar LilgeUniversity Health Network, Toronto, ON M5G 2C4, Canada.ORCID 0000-0001-5533-0005
Jennifer StoneGenetic Epidemiology Group, School of Population and Global Health, The University of Western Australia, Perth, WA 6009, Australia.ORCID 0000-0001-5077-0124

Funding

Cancer Australia APP1147677National Breast Cancer Foundation PS-15-040-1597582
6 · The paper itself

Abstract

Breast density is a strong intermediate endpoint to investigate the association between early-life exposures and breast cancer risk. This study investigates the association between early-life growth and breast density in young adult women measured using Optical Breast Spectroscopy (OBS) and Dual X-ray Absorptiometry (DXA). OBS measurements were obtained for 536 female Raine Cohort Study participants at ages 27-28, with 268 completing DXA measurements. Participants with three or more height and weight measurements from ages 8 to 22 were used to generate linear growth curves for height, weight and body mass index (BMI) using SITAR modelling. Three growth parameters (size, velocity and timing) were examined for association with breast density measures, adjusting for potential confounders. Women who reached their peak height rapidly (velocity) and later in adolescence (timing) had lower OBS-breast density. Overall, women who were taller (size) had higher OBS-breast density. For weight, women who grew quickly (velocity) and later in adolescence (timing) had higher absolute DXA-breast density. Overall, weight (size) was also inversely associated with absolute DXA-breast density, as was BMI. These findings provide new evidence that adolescent growth is associated with breast density measures in young adult women, suggesting potential mediation pathways for breast cancer risk in later life.

Indexed as

breast cancer riskbreast densitydual x-ray absorptiometryearly life growthoptical breast spectroscopythe Raine Study

Identifiers

PMID39001479
PMCPMC11240569

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.