Evidence map›Paper›PMID 39001465›Full record

ArticleCancers2024

Improved Pancreatic Cancer Detection and Localization on CT Scans: A Computer-Aided Detection Model Utilizing Secondary Features.

Mark Ramaekers, Christiaan G A Viviers, Terese A E Hellström, Lotte J S Ewals, Nick Tasios, Igor Jacobs, Joost Nederend, Fons van der Sommen, Misha D P Luyer, E/MTIC Oncology Collaborative Group

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Artificial intelligence in pancreatic cancer: applications in early detection, tumor staging, and survival prediction-a comprehensive review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  4. 3D Modelling for Preoperative Planning, Intraoperative Navigation, and Training in Pancreatic Surgery: A Systematic Review.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mark RamaekersDepartment of Surgery, Catharina Cancer Institute, Catharina Hospital Eindhoven, EJ 5623 Eindhoven, The Netherlands.ORCID 0000-0003-2120-7230
Christiaan G A ViviersDepartment of Electrical Engineering, Eindhoven University of Technology, AZ 5612 Eindhoven, The Netherlands.ORCID 0000-0001-6455-0288
Terese A E HellströmDepartment of Electrical Engineering, Eindhoven University of Technology, AZ 5612 Eindhoven, The Netherlands.ORCID 0009-0008-1521-4614
Lotte J S EwalsDepartment of Radiology, Catharina Cancer Institute, Catharina Hospital Eindhoven, EJ 5623 Eindhoven, The Netherlands.ORCID 0009-0002-3700-6409
Nick TasiosDepartment of Hospital Services and Informatics, Philips Research, AE 5656 Eindhoven, The Netherlands.
Igor JacobsDepartment of Hospital Services and Informatics, Philips Research, AE 5656 Eindhoven, The Netherlands.
Joost NederendDepartment of Radiology, Catharina Cancer Institute, Catharina Hospital Eindhoven, EJ 5623 Eindhoven, The Netherlands.ORCID 0000-0002-9905-5866
Fons van der SommenDepartment of Electrical Engineering, Eindhoven University of Technology, AZ 5612 Eindhoven, The Netherlands.ORCID 0000-0002-3593-2356
Misha D P LuyerDepartment of Surgery, Catharina Cancer Institute, Catharina Hospital Eindhoven, EJ 5623 Eindhoven, The Netherlands.ORCID 0000-0002-9483-1520
E/MTIC Oncology Collaborative Group

Funding

This research was funded by an Eindhoven AI Systems Institute (EAISI) Grant RVO characteristic TKI2112P08
6 · The paper itself

Abstract

The early detection of pancreatic ductal adenocarcinoma (PDAC) is essential for optimal treatment of pancreatic cancer patients. We propose a tumor detection framework to improve the detection of pancreatic head tumors on CT scans. In this retrospective research study, CT images of 99 patients with pancreatic head cancer and 98 control cases from the Catharina Hospital Eindhoven were collected. A multi-stage 3D U-Net-based approach was used for PDAC detection including clinically significant secondary features such as pancreatic duct and common bile duct dilation. The developed algorithm was evaluated using a local test set comprising 59 CT scans. The model was externally validated in 28 pancreatic cancer cases of a publicly available medical decathlon dataset. The tumor detection framework achieved a sensitivity of 0.97 and a specificity of 1.00, with an area under the receiver operating curve (AUROC) of 0.99, in detecting pancreatic head cancer in the local test set. In the external test set, we obtained similar results, with a sensitivity of 1.00. The model provided the tumor location with acceptable accuracy obtaining a DICE Similarity Coefficient (DSC) of 0.37. This study shows that a tumor detection framework utilizing CT scans and secondary signs of pancreatic cancer can detect pancreatic tumors with high accuracy.

Indexed as

artificial intelligencecomputed tomographycomputer-aided detectiondeep learningearly detectionpancreatic ductal adenocarcinomasecondary features

Identifiers

PMID39001465
PMCPMC11240790

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.