Mismatch Repair (MMR) Gene Mutation Carriers Have Favorable Outcome in Colorectal and Endometrial Cancer: A Prospective Cohort Study.

Jiunn-Tyng Yeh, Hung-Pin Peng, Fei-Hung Hung, Chen-Fang Hung, Ling-Ling Hsieh, An-Suei Yang, Yong Alison Wang

Abstract read

In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiunn-Tyng YehDepartment of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan.ORCID 0000-0003-2595-1892

Hung-Pin PengBiomedical Translation Research Center, Academia Sinica, Taipei 11571, Taiwan.ORCID 0000-0002-9398-8120

Fei-Hung HungHealth Data Analytics and Statistics Center, Office of Data Science, Taipei Medical University, Taipei 11013, Taiwan.ORCID 0000-0001-9453-916X

Chen-Fang HungDepartment of Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan.

Ling-Ling HsiehDepartment of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan.

An-Suei YangGenomics Research Center, Academia Sinica, Taipei 11571, Taiwan.ORCID 0000-0002-4699-873X

Yong Alison WangDepartment of Internal Medicine, Koo Foundation Sun Yat-Sen Cancer Center, Taipei 11259, Taiwan.ORCID 0000-0001-7361-348X

Funding

Ministry of Health and Welfare MOHW107-TDU-B-212-114021, MOHW108-TDU-B-212-124021, MOHW109-TDU-B-212-134021, MOHW110-TDU-B-212-144021

6 · The paper itself

Abstract

Germline (Lynch syndrome, LS) and somatic deficiencies of mismatch repair proteins (MMRd) are linked to colorectal and endometrial cancer; however, their prognostic impact in Asian populations remains unclear. This prospective cohort study aimed to determine the prevalence and outcome of germline and somatic MMRd in cancer patients suspected of LS. Patients with colorectal or endometrial cancer suspected of LS were enrolled and underwent gene sequencing for germline MMRd (gMMRd) and immunohistochemistry staining of MMR proteins in a subset of the pathological samples (pMMRd). Among the 451 enrolled patients, 36 patients were gMMRd (+). Compared with gMMRd (-) patients, the 10-year relapse-free survival in gMMRd (+) patients was significantly higher (100% vs. 77.9%;

Indexed as

colorectal cancerDNA mismatch repairendometrial cancerhigh-throughput nucleotide sequencingLynch syndrome

Identifiers

PMID39001404

DOI10.3390/cancers16132342

PMCPMC11240388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.