Evidence map›Paper›PMID 39001402›Full record

ArticleCancers2024

Unprocessed snRNAs Are a Prognostic Biomarker and Correlate with a Poorer Prognosis in Colorectal Cancer.

Víctor Escrich, Cristina Romero-Aranda, Rosario López, María de Toro, Ángela Metola, Begoña Ezcurra, Eva Gómez-Orte, Juan Cabello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Víctor EscrichOncology Area, Center for Biomedical Research of La Rioja-CIBIR, 26006 Logrono, Spain.ORCID 0000-0001-8810-467X
Cristina Romero-ArandaOncology Area, Center for Biomedical Research of La Rioja-CIBIR, 26006 Logrono, Spain.ORCID 0000-0003-2877-7471
Rosario LópezScientific Computing Group (GRUCACI), University of La Rioja, 26006 Logroño, Spain.ORCID 0000-0002-9069-395X
María de ToroOncology Area, Center for Biomedical Research of La Rioja-CIBIR, 26006 Logrono, Spain.
Ángela MetolaOncology Area, Center for Biomedical Research of La Rioja-CIBIR, 26006 Logrono, Spain.ORCID 0000-0001-5365-5447
Begoña EzcurraOncology Area, Center for Biomedical Research of La Rioja-CIBIR, 26006 Logrono, Spain.ORCID 0000-0001-7211-2616
Eva Gómez-OrteOncology Area, Center for Biomedical Research of La Rioja-CIBIR, 26006 Logrono, Spain.ORCID 0000-0001-6802-1746
Juan CabelloOncology Area, Center for Biomedical Research of La Rioja-CIBIR, 26006 Logrono, Spain.ORCID 0000-0002-3835-0116

Funding

Ministerio de Ciencia e Innovación (Spain) grant PID2021 - 127388NB - I00
6 · The paper itself

Abstract

The human Integrator complex is a set of 15 subunits that mediates processing of small nuclear RNAs (snRNAs), and which later participates in splicing messenger RNAs (mRNAs). In addition, it controls the pause and release of RNA polymerase II (RNA pol II) at specific gene promoters in response to growth factors. Mutations in Integrator-complex subunit 6 (

Indexed as

colorectal cancerINTS6prognosissnRNA processing

Identifiers

PMID39001402
PMCPMC11240374

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.