Evidence map›Paper›PMID 39001393›Full record

ReviewCancers2024

Is There an Opportunity to De-Escalate Treatments in Selected Patients with Metastatic Hormone-Sensitive Prostate Cancer?

María Antonia Gómez-Aparicio, Fernando López-Campos, David Buchser, Antonio Lazo, Patricia Willisch, Abrahams Ocanto, Paul Sargos, Mohamed Shelan, Felipe Couñago

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. National Cancer Institute's Working Group on Biochemically Recurrent Prostate Cancer: Clinical Trial Design Considerations.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

María Antonia Gómez-AparicioDepartment of Radiation Oncology, Hospital Universitario de Toledo, 45007 Toledo, Spain.
Fernando López-CamposDepartment of Radiation Oncology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.ORCID 0000-0002-4077-0507
David BuchserDepartment of Radiation Oncology, Hospital Universitario Cruces, 48903 Barakaldo, Spain.
Antonio LazoDepartment of Radiation Oncology, Hospital Universitario Virgen de la Victoria, 29010 Malaga, Spain.
Patricia WillischDepartment of Radiation Oncology, Hospital Meixoeiro, 36214 Vigo, Spain.ORCID 0009-0004-5693-9786
Abrahams OcantoDepartment of Radiation Oncology, Hospital Universitario San Francisco de Asis and Hospital Vithas La Milagrosa, GenesisCare, 28002 Madrid, Spain.ORCID 0000-0002-6494-8197
Paul SargosDepartment of Radiation Oncology, Institut Bergonié, 33000 Bordeaux, France.
Mohamed ShelanDepartment of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, SwitzerlandORCID 0000-0002-6477-6655
Felipe CouñagoDepartment of Radiation Oncology, Hospital Universitario San Francisco de Asis and Hospital Vithas La Milagrosa, GenesisCare, 28002 Madrid, Spain.ORCID 0000-0001-7233-0234

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The treatment landscape for metastatic hormone-sensitive prostate cancer continues to evolve, with systemic treatment being the mainstay of current treatment. Prognostic and predictive factors such as tumour volume and disease presentation have been studied to assess responses to different treatments. Intensification and de-escalation strategies arouse great interest, so several trials are being developed to further personalize the therapy in these populations. Is there an optimal sequence and a possible option to de-intensify treatment in selected patients with a favourable profile? This and other goals will be the subject of this review.

Indexed as

androgen receptor signalling inhibitorsde-intensificationmetastatic hormone-sensitive prostate cancertreatment intensification

Identifiers

PMID39001393
PMCPMC11240449

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.